Yes相关蛋白与转录共激活因子在甲状腺乳头状癌组织的表达及其临床意义  

Expression and clinical significance of Yes-associated protein and transcriptional co-activator expression in papillary thyroid carcinoma

作　　者：石东亮[1] 陈亮[1] 杨文华[1] 杨猛[1] Shi Dongliang;Chen Liang;Yang Wenhua;Yang Meng(The Second Department of Thyroid and Breast Surgery,the Center Hospital of Cangzhou,Cangzhou 061001,China)

机构地区：[1]沧州市中心医院甲状腺乳腺外二科,061001

出　　处：《中华实验外科杂志》2019年第5期936-938,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨Yes相关蛋白(YAP)与转录共激活因子(TAZ)在甲状腺乳头状癌中的表达及两者之间的关系。方法采用免疫组织化学法分别检测108例甲状腺乳头状癌及相应癌旁正常甲状腺组织中YAP与TAZ的表达。应用SPSS 25.0统计软件进行分析。结果甲状腺乳头状癌组织及相应癌旁正常甲状腺组织中YAP的阳性表达率分别为71.3%,20.4%,差异有统计学意义(χ^2=56.410,P<0.05)。Ⅰ、Ⅱ期(74例)与Ⅲ、Ⅳ期(34例),肿瘤<1 cm(39例)与≥1 cm(69例),腋下淋巴结有转移(50例)与无转移(58例),甲状腺外有侵犯(52例)与无侵犯(56例)均与YAP的表达显著相关(χ^2=4.751、6.610、7.342、11.385,P<0.05),而年龄、性别及多灶性与之无明显相关(χ^2=0.447、0.226、0.268,P>0.05)。甲状腺乳头状癌组织及相应癌旁正常甲状腺组织中TAZ的阳性表达率分别为69.4%和22.2%,差异有统计学意义(χ^2=48.503,P<0.05)。Ⅰ、Ⅱ期(74例)与Ⅲ、Ⅳ期(34例),肿瘤<1 cm(39例)与≥1 cm(69例),腋下淋巴结有转移(50例)与无转移(58例),甲状腺外有侵犯(52例)与无侵犯(56例)均与TAZ的表达显著相关(χ^2=5.875、6.999、12.026、10.878,P<0.05),而年龄、性别及多灶性与TAZ的表达无明显相关(χ2=0.591、0.096、0.498,P>0.05)。甲状腺乳头状癌组织中YAP与TAZ均高表达,两者呈正相关(r=0.601,P<0.05)。结论甲状腺乳头状癌发生发展与YAP与TAZ异常高表达明显相关。Objective To study the expression of Yes-associated protein(YAP)and transcriptional co-activator(TAZ)in papillary thyroid carcinoma and their clinical significance.Methods The expression levels of YAP and TAZ were detected by immunohistochemistry in 108 cases of papillary thyroid carcinoma tissues and corresponding paracancerous normal tissues.Statisticalanalysis of data using the statistical product and service solutions 25.0 software.Results The expression level of YAP was 71.3%in papillary thyroid carcinoma tissues,whereas its expression level was 20.4%in the corresponding paracancerous normal tissues,with statistical significance(χ^2=56.410,P<0.05).The expression of YAP in papillary thyroid carcinoma tissues was significantly associated with clinical stage,tumor size,lymph node metastases and extrathyroid invasion(χ^2=4.751,6.610,7.342,11.385,P<0.05),but not to age,sex or multifocality(χ^2=0.447,0.226,0.268,P>0.05).The expression level of TAZ was 69.4%in papillary thyroid carcinoma tissues,whereas its expression level was 22.2%in the corresponding paracancerous normal tissues,with statistical significance(χ^2=48.503,P<0.05).The expression of TAZ in papillary thyroid carcinoma tissues was significantly correlated with clinical stage,tumor size,lymph node metastases and extrathyroid invasion(χ^2=5.875,6.999,12.026,10.878,P<0.05),but not to age,sex or multifocality(χ^2=0.591,0.096,0.498,P>0.05).YAP as well as TAZ was expressed highly in papillary thyroid carcinoma tissues.The expression of YAP and TAZ was positively correlated(r=0.601,P<0.05).Conclusion The high expression of YAP as well as TAZ is closely related to the development of papillary thyroid carcinoma.

关 键 词：Yes相关蛋白 转录共激活因子 甲状腺乳头状癌 基因表达 

分 类 号：R736.1[医药卫生—肿瘤]