皮肤恶性黑色素瘤的临床特征及预后因素分析  

Clinical Features and Prognosis of Patients with Cutaneous Malignant Melanoma

作　　者：余慧[1] 汪洁[1] 柳林[1] 杜坤[1] 苏江维[1] YU Hui;WANG Jie;LIU Lin(Ezhou Central Hospital,Ezhou,436000)

机构地区：[1]湖北省鄂州市中心医院,436000

出　　处：《实用癌症杂志》2019年第5期802-804,811,共4页The Practical Journal of Cancer

摘　　要：目的探讨皮肤恶性黑色素瘤(CMM)的临床特征及影响预后的因素。方法回顾性分析80例CMM患者的临床资料,以患者的性别、年龄、肿瘤部位、肿瘤大小、肿瘤厚度、肿瘤有无溃疡、肿瘤分期、淋巴结转移情况、乳酸脱氢酶(lactate dehydrogenase,LDH)水平、BRAF突变、治疗方法等因素进行分析,研究其对预后生存的影响。结果单因素分析显示:肿瘤部位、肿瘤大小、肿瘤厚度、肿瘤有无溃疡、肿瘤分期、淋巴结转移情况、LDH水平、BRAF基因状态、术后是否行辅助治疗9个因素是影响CMM患者生存预后因素(P <0. 05)。多因素分析显示:肿瘤厚度、肿瘤有无溃疡、肿瘤分期、BRAF基因状态是影响CMM患者生存时间的独立预后危险因素(P <0. 05)。结论肿瘤浸润深、肿瘤表面有溃疡、临床分期较晚、BRAF V600E突变的患者预后较差。Objective To analyze the clinical characteristics and prognostic factors of cutaneous malignant melanoma( CMM). Methods Clinical data of 80 CMM patients were retrospectively analyzed. The factors including patients’ gender,age,tumor site,tumor size,tumor thickness,tumor ulcer,tumor stage,lymph node metastasis,lactate dehydrogenase( LDH),BRAF mutation and treatment were analyzed to study its influence on prognosis and survival. Results Univariate analysis showed that 9 factors,including tumor site,tumor size,tumor thickness,tumor ulcer,tumor stage,lymph node metastasis,LDH level,BRAF gene status,and postoperative adjuvant therapy,were the prognostic factors of CMM patients( P < 0. 05). Multivariate analysis showed that tumor thickness,tumor ulcer,tumor stage and BRAF gene status were independent prognostic risk factors influencing survival time of CMM patients. Conclusion Patients with deep tumor infiltration,ulcer on tumor surface,late clinical stage and BRAF V600 E mutation had a poor prognosis.

关 键 词：皮肤恶性黑色素瘤 临床特征 预后因素 生存分析 

分 类 号：R739.5[医药卫生—肿瘤]