铁沉积测定在帕金森病诊断及鉴别诊断中的应用  

A review on evaluating application of abnormal iron deposition in brain on diagnosis and differential diagnosis of Parkinson's disease

作　　者：熊洧 唐北沙[2] 雷立芳[1] Xiong Wei;Tang Beisha;Lei Lifang(Department of Neurology,the Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅三医院神经内科,长沙410013 [2]中南大学湘雅医院神经内科,长沙410008

出　　处：《中华老年医学杂志》2019年第5期594-600,共7页Chinese Journal of Geriatrics

基　　金：湘雅三医院至善领跑人才计划(20170306).

摘　　要：帕金森病(PD)是一种常见的神经系统退行性疾病,目前诊断主要依赖于患者的临床表现及其对多巴胺能药物的反应,其临床诊断与病理诊断符合率只有70%~80%。研究发现,颅内铁沉积异常是PD疾病进展过程中重要的病理改变之一。因此,运用一些辅助手段探测PD患者颅内铁的异常沉积可为PD的早期诊断、鉴别诊断提供帮助。Parkinson's disease(PD)is a common neurological degenerative diseases, and its diagnosis mainly depends on a patient's clinical manifestations and the response to dopaminergic drugs.The coincidence rate between clinical diagnosis and pathological diagnosis for PD is only 70%-80%.It is found that abnormality of intracranial iron deposition is one of the important pathological changes in PD progression.Therefore, it can be helpful to detect the abnormal iron deposition in brain using MRI and Doppler sonography for early diagnosis and differential diagnosis of PD.

关 键 词：铁 帕金森病 诊断 

分 类 号：R742.5[医药卫生—神经病学与精神病学]