IMRT同步TP化疗方案治疗局部晚期非小细胞肺癌中期随访  

Mid-term follow-up study of patients with locally advanced non-small cell lung cancer treated with IMRT synchronized TP chemotherapy

作　　者：巴艳华[1] 单国用[1] 刘兴安[1] 王琳[1] 田希凤 Ba Yanhua;Shan Guoyong;Liu Xing’an;Wang Lin;Tian Xifeng(Zhengzhou People's Hospital,Zhengzhou 450003,Henan,China)

机构地区：[1]郑州人民医院,河南郑州450003

出　　处：《临床心身疾病杂志》2019年第3期43-47,共5页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨适形调强放射治疗同步TP化疗方案治疗局部晚期非小细胞肺癌的中期临床疗效。方法将100例局部晚期非小细胞肺癌患者按随机数字表法分为两组,每组50例。对照组给予适形调强放射治疗,实验组在对照组基础上给予TP化疗方案,1个月为1个疗程,连续治疗2个疗程。比较两组肿瘤控制率、不良反应发生状况、治疗前后T淋巴细胞亚群水平;随访1年,统计分析两组生存率、局部复发率、远处转移率、生存质量。结果实验组肿瘤控制率(76.0%)显著高于对照组(56.0%)(P<0.05);治疗后实验组CD3^+、CD4^+、CD4^+/CD8^+水平显著高于对照组(P<0.05或0.01),CD8^+水平显著低于对照组(P<0.0);两组不良反应发生率比较差异无统计学意义(P>0.05)。随访1年,实验组局部复发率(14.0%)、远处转移率(12.0%)显著低于对照组(32.0%、30.0%)(P<0.05),生存率(78.0%)高于对照组(68.0%),但差异无统计学意义(P>0.05),生存质量显著优于对照组(P<0.05)。结论适形调强放射治疗同步TP化疗方案治疗局部晚期非小细胞肺癌,有助于降低局部复发率、远处转移率,提高局部控制率,增强机体免疫功能,改善患者生存质量。Objective To investigate the mid-term clinical effects of patients with locally advanced non-small cell lung cancer treated with IMRT synchronized TP chemotherapy.Methods 100 patients with locally advanced non-small cell lung cancer were divided into two groups,50 cases in each group.The control group was given IMRT treatment.On this basis,the experimental group was given TP chemotherapy for 2 courses(1 month for 1 course).The tumor control rate,adverse reaction status,T lymphocyte subsets before and after treatment of the two groups were compared.After treatment for 1 year,the survival rate,local recurrence rate,distant metastasis rate and quality of life were statistically analyzed.Results The tumor control rate of the experimental group(76.0%)was higher than that of the control group(56.0%)(P<0.05).The levels of CD3^+、CD4^+ and CD4^+/CD8^+ in the experimental group were higher than those in the control group after treatment(P<0.05 or 0.01),and the level of CD8^+ was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group(P>0.05).After 1 year of treatment,the local recurrence rate and the distant metastasis rate of the experimental group(14.0%,12.0%)were significantly lower than those of the control group(32.0%,30.0%)(P<0.05).The survival rate of the experimental group(78.0 %)was higher than that of the control group(68.0%),but the difference was not statistically significant(P>0.05).The quality of life of the experimental group was significantly better than that of the control group(P<0.05).Conclusion IMRT synchronized TP chemotherapy for patients with locally advanced non-small cell lung cancer can help reduce local recurrence rate,distant metastasis rate,improve local control rate,enhance immune function,and improve quality of life.

关 键 词：非小细胞肺癌 局部 晚期 TP化疗方案 适形调强放射治疗 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤] R730.5[医药卫生—临床医学]