脑脊液酶谱在阿尔茨海默病中的研究进展  

Advances of cerebrospinal fluid enzyme spectrum in Alzheimer′s disease

作　　者：张齐皓 刘辰庚[1] 王培昌[1] ZHANG Qihao;LIU Chengeng;WANG Peichang(Department of Clinical Laboratory,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;the First School of Clinical Medicine,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院检验科,北京100053 [2]首都医科大学第一临床医学院,北京100053

出　　处：《中国医药导报》2019年第14期19-22,共4页China Medical Herald

基　　金：国家自然科学基金青年基金项目(81401734);首都医科大学本科生科研训练项目(XSKY2018148);北京市医院管理局青年人才培养“青苗”计划(QML20150804);国家重点研发计划项目(2016YFC1306301)

摘　　要：阿尔茨海默病(AD)是一种与年龄相关的、渐进性的神经系统变性疾病,是导致老年期痴呆最常见的病因。AD进展缓慢,病情呈进行性加重,在AD的发生发展中,不同的阶段伴随着相应的病理生理改变,在AD痴呆阶段之前还存在一个从几年到几十年的痴呆前阶段,而AD患者脑脊液中的酶可作为反映疾病变化过程的生物标志物,对于AD的早期诊治具有重要的意义。本文将对脑脊液中的一些酶在AD中的研究现状进行综述。Alzheimer′s disease(AD)is an age-related and progressive neurodegenerative disease,which is the most common disease leading to dementia.AD develops slowly and becomes severe progressively.In the development of AD,different stages are accompanied with corresponding pathophysiological changes,where the enzymes in the cerebrospinal fluid of patients with AD can be used as biomarkers to reflect the developing process of AD,and before the dementia stage of AD,there is a preclinical stage ranging from years to decades.In this way,it is of great significance to the early diagnosis and treatment of AD.This review focuses on the current research of some enzymes in the cerebrospinal fluid of AD.

关 键 词：阿尔茨海默病 脑脊液 酶 BACE1 KLK6 基质金属蛋白酶 

分 类 号：R742[医药卫生—神经病学与精神病学]