非小细胞肺癌患者血清癌胚抗原、神经元特异性烯醇化酶、胃泌素释放肽前体水平与患者预后关系研究  

Relationship between serum CEA, NSE and proGRP levels and prognosis in patients with non-small cell lung cancer

作　　者：应晓珍[1] 林霞[2] 鲍黎明[1] 吴鹤[1] 张琦 YING Xiao-zhen;LIN Xia;BAO Li -ming;WU He;ZHANG Qi(Department of Radiotherapy, Lishui Central Hospital, Lishui, Zhejiang 323000, China)

机构地区：[1]丽水市中心医院放疗科,浙江丽水323000 [2]丽水市中心医院胸外科,浙江丽水323000

出　　处：《中国卫生检验杂志》2019年第10期1211-1213,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的分析癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、胃泌素释放肽前体(proGRP)在非小细胞肺癌(NSCLC)患者中的水平,并探讨其判断患者预后的临床价值。方法选取本院行手术治疗的NSCLC患者、肺部良性病变(BPD)患者与健康体检者,比较3组受试者的血清CEA、NSE、proGRP水平;并比较NSCLC组患者手术前后以及术后有无复发转移者血清CEA、NSE、proGRP水平的差异。结果NSCLC组患者血清CEA、NSE、proGRP水平均高于BPD组和对照组,差异有统计学意义(P<0.05);NSCLC组患者术后血清CEA、NSE、proGRP水平均较术前降低,差异有统计学意义(P<0.05)。术后出现复发转移患者的血清CEA、NSE、proGRP水平均明显高于无复发转移患者,差异有统计学意义(P<0.05)。结论NSCLC患者血清CEA、NSE、proGRP水平呈升高状态,与患者的肿瘤负荷和术后复发转移情况相关,有利于评价NSCLC的发生发展与预后。Objective To analyze the levels of carcinoembryonic antigen ( CEA), neuron specific enolase ( NSE) and pro - gastrin - releasing peptide ( proGRP) in patients with non - small cell lung cancer ( NSCLC), and to explore the clinical value of determining patients’prognosis. Methods Patients with NSCLC, patients with benign pulmonary disease ( BPD) and healthy subjects were selected. Serum CEA, NSE and proGRP levels were compared among the three groups. The differences of serum CEA, NSE and proGRP levels in the patients from NSCLC group before and after surgery, with tumor recurrence and without recurrence were compared. Results Serum CEA, NSE, and proGRP levels were higher in the NSCLC group than that in the BPD group and the control group, with the differences statistically significant ( P < 0. 05). The serum CEA, NSE, and proGRP levels in the NSCLC group after surgery were lower than that before surgery, and the differences were statistically significant ( P < 0. 05). Postoperative following - up showed that serum CEA, NSE, and proGRP levels were significantly higher in patients with recurrence and metastasis than in patients without recurrence and metastasis, and the differences were statistically significant ( P < 0. 05). Conclusion The serum levels of CEA, NSE and proGRP in patients with NSCLC are elevated, and they are closely related to the tumor burden and postoperative recurrence and metastasis. The detection of the above indicators is of great significance for the diagnosis and prognosis of NSCLC patients.

关 键 词：非小细胞肺癌 癌胚抗原 神经元特异性烯醇化酶 胃泌素释放肽前体 预后 

分 类 号：R734.2[医药卫生—肿瘤]