基于3D打印牺牲阳模的异型截面微流道便捷加工  

Facile Fabrication of Microchannel with Unconventional Cross-Section Using 3D Printed Sacrificial Mould

作　　者：唐文来 樊宁 李宗安 项楠[3] 杨继全 TANG Wen-Lai;FAN Ning;LI Zong-An;XIANG Nan;YANG Ji-Quan(Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210023, China;Nanjing Institute of Intelligent High-end Equipment Industry Co., Ltd., Nanjing 210042, China;Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing 211189, China)

机构地区：[1]南京师范大学电气与自动化工程学院江苏省三维打印装备与制造重点实验室,南京210023 [2]南京智能高端装备产业研究院有限公司,南京210042 [3]东南大学机械工程学院江苏省微纳生物医疗器械设计与制造重点实验室,南京211189

出　　处：《分析化学》2019年第6期838-845,共8页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.51805272);江苏省重点研发计划项目(Nos.BE2018010-1;BE2018010-2);江苏省自然科学基金项目(No.BK20180730);江苏省高等学校自然科学研究项目(No.18KJB460022)资助~~

摘　　要：提出了一种基于3D打印牺牲阳模的异型截面微流道便携加工方法,以探究流道截面对微粒惯性聚焦行为的调控作用。利用皮秒激光切割技术加工任意形状的喷嘴微孔,借助桌面级FDM打印机可方便地制造出所需的异型截面流道阳模。结合通用的PDMS倒模复制技术和阳模溶解技术,可在无需键合密封工艺的情况下获得完整的PDMS微流控芯片。为验证本方法的有效性,设计并成功加工出具有方形、半椭圆形和三角形截面的微流道,发现可通过控制打印材料的挤出量灵活调整加工流道截面的尺寸。最后,搭建了实验平台系统,研究微粒在半椭圆形和三角形微流道内的惯性聚焦行为,以探究异型截面在微粒惯性操控方面的影响机制。结果表明,随着流体流量的逐渐增加,在半椭圆形和三角形流道内的微粒将逐渐横向迁移运动至靠近流道截面边长的中心附近,最终形成3个稳定的平衡位置。In this work, a novel 3 D printed mould-removal method was proposed to fabricate the microchannels with unconventional cross-sections. By modifying the orifice shape of extrusion nozzle with picosecond laser cutting technology, the ABS microchannel moulds with arbitrary cross-sections could be facilely printed by using an ordinary desktop FDM printer. After conducting the PDMS casting and ABS dissolving, the all-PDMS microfluidic chips could be easily produced without complex bonding process. To verify effectiveness of the proposed method, the microchannels with square, semielliptical and triangular sections were designed and successfully fabricated. It was also found that the size of the microchannel section could be flexibly adjusted by just controlling the ABS extrusion amount during the channel mould printing. At last, to explore the effects of channel section on the particle inertial focusing behaviours, the particle lateral migrations in the semielliptical and triangular microchannels were systematically investigated. The results showed that, with the increase of flow rate, the particles flowing in the microchannels moved gradually and laterally to the regions near the centers of each channel edge, and finally forming three stable equilibrium positions for both semielliptical and triangular microchannels.

关 键 词：微流控 3D打印 微粒操控 惯性聚焦 微加工 

分 类 号：TP391.73[自动化与计算机技术—计算机应用技术] TN492[自动化与计算机技术—计算机科学与技术]