雌激素调节失血性休克免疫功能的作用与机制  

Role and mechanism of estrogen regulating immune function following hemorrhagic shock

作　　者：王鹏 李曙光[1] 赵自刚[1] WANG Peng;LI Shu-Guang;ZHAO Zi-Gang(Institute of Microcirculation,Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院微循环研究所

出　　处：《中国免疫学杂志》2019年第10期1277-1280,I0002,I0003,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(81670446)

摘　　要：雌激素具有多种生物学活性,已广泛应用于临床。免疫功能紊乱是失血性休克发生全身炎症反应失控乃至脓毒症的主要触发因素。本文从脾细胞、T淋巴细胞、树突状细胞、Kupffer细胞、巨噬细胞等方面,综述雌激素调节失血性休克免疫功能的作用与机制,以期拓展雌激素的临床应用,为防治重症失血性休克提供新策略。Estrogen has many biological activities and has extensive clinical applications.Immune function disorder plays a triggering effect of leading to un-control systemic inflammatory response and sepsis following hemorrhagic shock.The present paper focuses on splenocytes,T lymphocytes,dendritic cells,Kupffer cells and macrophages,and reviews the role and mechanism of estrogen regulating immune function following hemorrhagic shock.Thus,this review expands the clinical application of estrogen,and provides a novel approach for treatment of severe hemorrhagic shock.

关 键 词：雌激素 失血性休克 免疫功能 

分 类 号：R364.14[医药卫生—病理学] R977.12[医药卫生—基础医学]