维生素D与缺血性卒中的预防和治疗  

Vitamin D and prevention and treatment of ischemic stroke

作　　者：李承[1] 方芳 Li Cheng;Fang Fang(Department of Neurology,the Ninth People's Hospital of Chongqing,Chongqing,400700;Department of Neurology,University-Town Hospital of Chongqing Medical University,Chongqing,401331)

机构地区：[1]重庆市第九人民医院神经内科,400700 [2]重庆医科大学附属大学城医院神经内科,401331

出　　处：《国际脑血管病杂志》2019年第3期206-211,共6页International Journal of Cerebrovascular Diseases

摘　　要：维生素D是一种脂溶性维生素,具有类固醇激素的功能。已在多种靶细胞中发现了维生素D受体,包括神经元和神经胶质细胞,在脑内发挥神经免疫调节和神经保护作用。大量研究显示,血清维生素D水平与缺血性卒中发病风险、严重程度和转归密切相关,提示补充维生素D可能起到预防和治疗缺血性卒中的作用。但是,近年来的研究结果不尽一致。Vitamin D is a fat-soluble vitamin which can function as a steroid hormone.Vitamin D receptors have been found in many target cells,such as neurons and glial cells,exerting neuroimmunomodulation and neuroprotection in the brain.A large number of studies have shown that serum vitamin D levels are closely related to the onset,severity and outcome of ischemic stroke,suggesting that vitamin D supplementation may play a role in the prevention and treatment of ischemic stroke.However,the results of recent studies are not consistent.

关 键 词：卒中 脑缺血 维生素D 

分 类 号：R743.3[医药卫生—神经病学与精神病学]