非高密度脂蛋白与腔隙性脑梗死认知障碍的相关性研究  

Correlation between non-high-density lipoprotein and cognitive impairment in lacunar infarction

作　　者：杨兴东[1] 曾一君[2] 唐晓梅[1] 冯研[1] 史冬梅[1] 刘磊[1] 余秋瑾 于逢春[1] YANG Xingdong;ZENG Yijun;TANG Xiaomei(Department of Neurology,Beijing Haidian Hospital,Beijing 100080,China)

机构地区：[1]北京市海淀医院,北京大学第三医院海淀院区神经内科,北京100080 [2]北京市丰台医院神经内科,北京100070

出　　处：《中风与神经疾病杂志》2019年第5期412-415,共4页Journal of Apoplexy and Nervous Diseases

基　　金：海淀医院院级科研基金面上项目

摘　　要：目的探讨非高密度脂蛋白(non-HDL-C)与腔隙性脑梗死(LI)认知障碍的关系。方法回顾性分析2017年1月~2018年11月就诊于我院神经内科符合LI诊断标准的患者171例,参照MoCA量表进行评分,分为认知障碍组和非认知障碍组,测量总胆固醇及高密度脂蛋白,并计算non-HDL-C水平。对non-HDL-C与LI认知障碍之间的关系进行Logistic多因素回归分析。结果调整潜在混杂因素后,与non-HDL-C最低四分位组相比,non-HDL-C最高四分位组患者认知障碍患病率较高[OR=3.806(95%CI):1.475~9.822,P=0.006]。随着non-HDL-C的增高,患者认知障碍可能进一步增加(P for trend=0.004)。结论Non-HDL-C与认知障碍呈现正相关,且随着non-HDL-C水平增高,认知障碍可能会出现增加的趋势。Objective To investigate the relationship between non-high-density lipoprotein(non-HDL-C) and cognitive impairment in lacunar infarction(LI).Methods A retrospective analysis of 171 patients with neurological diagnostic criteria in our department of neurology from January 2017 to November 2018 was performed.The scores were classified according to the MoCA scale and divided into cognitive impairment and non-cognitive disorders.Total cholesterol and high density lipoprotein were measured and non-HDL-C levels were calculated.Logistic multivariate regression analysis was performed on the relationship between non-HDL-C and LI cognitive impairment.Results After adjusting for potential confounders,the prevalence of cognitive impairment was higher in the highest quartile of non-HDL-C compared with the lowest quartile of non-HDL-C [ OR =3.806(95% CI):1.475~9.822,P =0.006].With the increase in non-HDL-C,the patient’s cognitive impairment may increase further(p for trend=0.004).Conclusion Non-HDL-C is positively correlated with cognitive impairment,and with the increase of non-HDL-C level,cognitive impairment may increase.

关 键 词：腔隙性脑梗死 认知功能障碍 缺血性卒中 胆固醇 非高密度脂蛋白 

分 类 号：R743[医药卫生—神经病学与精神病学]