异甘草酸镁注射液预防血液肿瘤化疗相关肝损伤多中心临床协作研究  

A multicenter study of magnesium isoglycyrrhizinate injection to prevent liver injury induced by chemotherapy in hematological malignancies

作　　者：李国辉 陈任安 王文清 秦炜炜 赵万红[2] 姚亚洲[3] 张启科[4] 张亚莉 黄国强[6] 田培军[7] 张福林[8] 贺鹏程[9] 葛繁梅[10] 王一[11] 宋艳萍[12] 耿惠[13] 王存邦 王景昌[15] 刘利 LI Guohui;CHEN Renan;WANG Wenqing(Tangdu Hospital of Air Force Medical University,Xi’an 710038)

机构地区：[1]空军军医大学唐都医院,西安710038 [10]延安大学附属医院,延安716000 [11]陕西省人民医院,西安710068 [12]西安市中心医院,西安710004 [13]青海大学附属医院,西宁810001 [14]兰州战区陆军总院,兰州730050 [15]解放军第三医院,宝鸡721004 [2]西安交通大学第二附属医院,西安710004 [3]陕西省宝鸡市中心医院,宝鸡721008 [4]甘肃省人民医院,兰州730000 [5]陕西省咸阳市中心医院,咸阳712000 [6]陕西省汉中市中心医院,汉中723000 [7]陕西省安康市中心医院,安康725000 [8]陕西省延安市人民医院,延安716000 [9]西安交通大学第一附属医院,西安710061

出　　处：《陕西医学杂志》2019年第6期787-790,共4页Shaanxi Medical Journal

基　　金：空军军医大学唐都医院创新发展基金资助项目(2016LCYJ014)

摘　　要：目的:观察和评价在大样本血液肿瘤患者人群中采用异甘草酸镁注射液预防抗肿瘤化疗相关性急性肝损伤的有效性和安全性。方法:对511例患者化疗开始前1d给予200mg的异甘草酸镁注射液静脉滴注,1次/d,连续用药至1个化疗疗程结束后,异甘草酸镁注射液用药≥7d。观察化疗前后肝脏生化指标的变化及输注异甘草酸镁的不良反应。结果:共入组1567例接受化疗的恶性血液病患者,纳入全分析集(FAS)分析1511例。化疗后ALT、AST、T-BIL、D-BIL、ALP及GGT较化疗前均无增高。化疗过程部分患者出现不同程度肝损伤,其中TBIL异常率最高,为15.19%。化疗前肝功能异常的患者,化疗后肝功能较前好转,化疗前后肝功能指标改善有统计学差异。患者在治疗前后肾功能指标、电解质、血压等比较,没有统计学差异。结论:异甘草酸镁注射液与化疗药物同时应用,能够防治血液肿瘤化疗药物相关性肝损伤,明显降低其发生率。Objective:To observe and evaluation the efficacy and safety of magnesium isoglycyrrhizinate injection to prevent liver injury induced by chemotherapy in hematological malignancies.Methods:The magnesium isoglycyrrhizinate injection was given 200mg per day before the chemotherapy,and after the end of chemotherapy courses.magnesium isoglycyrrhizinate injection was used for at least 7 days.The changes of liver biochemical indexes before and after chemotherapy and the adverse reactions of magnesium Isoglycyrrhizinate Injection were observed.Results:Among the 1567 cases of hematological malignancies received chemotherapy,1511 cases were included in the FAS analysis.After chemotherapy,the levels of ALT,AST,TBIL,DBIL,ALP and GGT were not increased compared with those before chemotherapy.Some patients suffered from different degrees of liver injury during chemotherapy.Among them,the most common abnormalities were TBIL up to 15.19%.The liver function of patients with abnormal liver function before chemotherapy got better.There was significant difference in the improvement of liver function before and after chemotherapy.There was no statistical difference in renal function index,electrolyte and blood pressure before and after treatment.Concusions:The application of magnesium isoglycyrrhizinate injection with chemotherapeutic drugs can prevent the liver injury of chemotherapeutic drugs.

关 键 词：药物性肝损伤 化学治疗 急性肝损伤 异甘草酸镁注射液 预防性应用 

分 类 号：R733[医药卫生—肿瘤]