MYRF与中枢神经系统髓鞘发育  

MYRF and Myelination in the Central Nervous System

作　　者：杜君卿 黄浩[1] 杨爱芬[1] DU Junqing;HUANG Hao;YANG Aifen(Institute of Life Sciences,Hangzhou Normal University,Hangzhou 310036,China)

机构地区：[1]杭州师范大学生命科学研究院

出　　处：《杭州师范大学学报（自然科学版）》2019年第3期249-254,299,共7页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(31771621);浙江省自然科学基金项目(LQ16C090004,LQ19C090001)

摘　　要：在脊椎动物的中枢神经系统中,少突胶质细胞围绕神经元轴突形成髓鞘,使神经冲动可以沿轴突跳跃式快速传导.髓鞘的异常会导致多种神经系统疾病甚至引起死亡.MYRF作为一种转录因子,是目前已知的OLs分化和髓鞘维持的最关键调控因子之一,对MYRF的研究将是髓鞘发育和再生机制的重要内容.文章就近年来MYRF调控中枢神经系统髓鞘发育的研究进展进行了总结.Myelin sheath formed by oligodendrocytes(OLs)around the neuron axons accelerates the conduction of nerve electrical impulses dozens of times in the central nervous system(CNS)of vertebrates.Anomalous myelination causes multiple neural diseases and even death.As a transcriptional factor,MYRF is one of the most important factors involved in OLs differentiation and myelin maintenance.The investigation of MYRF will be the key item to understand the mechanisms of myelination and remyelination.This paper summarizes the progresses about the regulation of CNS development by MYRF over the past decade.

关 键 词：MYRF 少突胶质细胞 髓鞘形成 髓鞘再生 转录因子 

分 类 号：Q189[生物学—神经生物学]