化疗联合中药序贯口服治疗晚期非小细胞肺癌的临床研究  

Clinical Observation of Chemotherapy Combined with Sequential Therapy of Chinese Medication in Treatment of NSCLC of Advanced Stage

作　　者：于小伟[1] 唐丽萍[1] 李敏[1] 徐川[1] 仝欣[1] 方美花[1] 陶智会[1] 靳永杰 YU Xiaowei;TANG Liping;LI Min;XU Chuan;TONG Xin;FANG Meihua;TAO Zhihui;JIN Yongjie(Shanghai Jiading Hospital of TCM, Shanghai 201899, China)

机构地区：[1]上海市嘉定区中医医院

出　　处：《中医药信息》2019年第3期91-94,共4页Information on Traditional Chinese Medicine

基　　金：上海市卫生和计划生育委员会上海市中医药发展办公室中医优势病种培育项目(No.zybz-2017054);上海市嘉定区农业和社会事业科研项目(No.JDKW-2016-W22)

摘　　要：目的:观察化疗联合中药序贯口服治疗晚期非小细胞肺癌的临床疗效。方法:将经影像学及病理或细胞学确诊为晚期非小细胞肺癌患者41例,随机分为治疗组和对照组,治疗组20例,对照组21例,对照组予PC或TC方案化疗,治疗组予PC或TC方案化疗加中药序贯口服,化疗4周期后观察两组在中医证候、临床受益率、全身状态和免疫指标等方面的差别,评价两组临床疗效。结果:治疗组临床症状改善总有效率90%,对照组临床症状改善总有效率60%,差异有统计学意义(P<0.05);治疗组临床受益率90%,对照组临床受益率60%,差异有统计学意义(P<0.05);治疗组治疗后免疫指标变化总有效率80%,对照组治疗后免疫指标变化总有效率50%,差异有统计学意义(P<0.05);治疗组治疗后全身状态变化总有效率90%,对照组治疗后全身状态变化总有效率45%,差异有统计学意义(P<0.05)。结论:化疗联合中药序贯口服在治疗晚期非小细胞肺癌方面疗效确切,具有临床推广意义。Objective: To observe the curative effects of chemotherapy combined with sequential therapy of Chinese medication in the treatment of non-small cell lung cancer(NSCLC) of advanced stage. Methods: A total of 41 patients diagnosed with NSCLC by imaging and pathological or cytological method were randomly divided into the control group( n =21) and the treatment group( n =20). The control group was intervened with PC or TC chemotherapy plan;on which basis, the treatment group was also intervened with sequential therapy of Chinese medication. After four weeks of chemotherapy, the differences in TCM syndrome, clinical effect, general body state, and immune indexes were compared between the two groups. Results: The total effective rate of improving clinical symptoms was 90% in the treatment group, which was significantly higher than 60% in the control group( P <0.05). The clinical benefit rate was 90% in the treatment group, which was significantly higher than 65% in the control group( P <0.05). The total effective rate of immune indexes was 80% in the treatment group, which was greatly higher than 50% in the control group( P <0.05). The total effective rate of general body state was 90% in the treatment group, which was greatly higher than 45% in the control group( P <0.05). Conclusion: There is a remarkable curative effect of chemotherapy combined with sequential therapy of Chinese medication in the treatment of NSCLC of advanced stage, which is worthy of clinical promotion.

关 键 词：中西医结合 非小细胞肺癌 中药序贯 香砂六君子汤 旋覆代赭汤 益气固本抗癌方 

分 类 号：R734.2[医药卫生—肿瘤]