ZFX在肝内胆管癌中的表达及临床意义  

Expression and clinical significance of ZFX in intrahepatic cholangiocarcinoma

作　　者：林群 刘付宝[1] 余孝俊[1] 谢坤[1] 赵义军[1] Lin Qun;Liu Fubao;Yu Xiaojun(Dept of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院肝胆胰外科,合肥230022

出　　处：《安徽医科大学学报》2019年第5期813-816,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81702829)

摘　　要：目的探讨X染色体耦联锌指蛋白(ZFX)在肝内胆管癌(ICC)组织中的表达及其临床意义。方法免疫组织化学检测60例ICC组织、50例癌旁组织及15例肝内胆管结石组织标本中ZFX的表达情况,分析ZFX表达与患者临床病理特征及预后的关系。结果 ICC组织中ZFX表达率为73.3%,明显高于癌旁组织(38.0%)和肝内胆管结石组织(26.7%)(P<0.001)。在血清癌胚抗原(CEA)升高、肿瘤分化程度低、有淋巴结转移、TNM分期高的患者ICC组织中ZFX高表达率较高,在淋巴结转移和TNM分期中表达差异无统计学意义,在血清CEA和肿瘤分化程度中的表达差异有统计学意义(P<0.05)。生存分析表明ZFX高表达组患者术后总体生存率明显低于ZFX低表达组(P=0.006)。Cox比例风险回归模型分析表明ZFX是ICC患者的独立预后因子(HR=2.635, 95%CI:1.044～6.651,P=0.040)。结论 ZFX在ICC组织中表达增加,且ZFX高表达与ICC患者恶性病理特征及不良预后密切相关。Objective To investigate the expression and clinical significance of zinc-finger protein X-linked(ZFX)in intrahepatic cholangiocarcinoma(ICC). Methods The ZFX expression were detected by immunohistochemical technique in 60 cases of ICC tissue,50 cases of adjacent tissue and 15 cases of hepatolithiasis tissue,and the relations of ZFX expression with the clinicopathologic characteristics and prognosis of the patients were statistically analyzed. Results The high expression rate of ZFX in ICC tissues was 73.3%,which were significantly higher than those in adjacent tissues (38.0%) and hepatolithiasis tissue(26.7%)( P <0.001). The high expression rate of ZFX was higher in ICC tissues with elevated serum CEA,low tumor differentiation,lymph node metastasis,and high TNM stage. There was no statistically significant difference in lymph node metastasis and TNM staging. The expression of carcinoembryonicantigen (CEA) and tumor differentiation was statistically significant( P <0.05). Kaplan-Meier survival analysis showed that the postoperative overall survival was lower in patients with high ZFX expression compared with those with low expression( P =0.006). Multivariate analysis further demonstrated that ZFX was an independent prognostic factor for ICC patients( HR =2.635,95% CI :1.044~6.651,P =0.040). Conclusion ZFX expression is increased in ICC tissue,and its overexpression is closely related to malignant pathological profiles and dismal prognosis of the ICC patients.

关 键 词：X染色体耦联锌指蛋白 肝内胆管癌 预后 

分 类 号：R735.7[医药卫生—肿瘤]