脾多肽注射液联合TACE治疗晚期肝癌临床观察  

Effect of splenic peptide injection combined with TACE in the treatment of advanced hepatocellular carcinoma

作　　者：陆晓[1] 秦方方[1] 段成洲 尹治清 郭永坤 LU Xiao;QIN Fang-fang;DUAN Cheng-zhou;YIN Zhi-qing;GUO Yong-kun(Department of Interventional Anyang Cancer Hospital Anyang 455000,P.R.China)

机构地区：[1]安阳市肿瘤医院介入科,河南安阳455000

出　　处：《社区医学杂志》2018年第24期1788-1791,共4页Journal Of Community Medicine

摘　　要：目的近年来肝癌发病率不断升高,针对晚期肝癌患者治疗的研究不断增多。本研究分析脾多肽注射液联合肝动脉插管化疗栓塞术(transcatheter arterial chemoembolization,TACE)对晚期肝癌临床效果及对患者肝功能影响。方法在2015-01-01-2017-12-31安阳市肿瘤医院介入科收治的晚期肝癌患者中,按照匹配的方法分别选择对照组54例,观察组54例进行分析。对照组进行常规TACE治疗,观察组采用脾多肽注射液联合TACE治疗,对比两组治疗效果、肝功能指标及肿瘤标志物水平。结果观察组治疗总有效率为96.3%,高于对照组的81.48%,χ~2=6.004,P=0.014。治疗后,观察组谷丙转氨酶(alanine aminotransferase,ALT)水平为(75.13±7.58)IU/L,高于对照组的(73.01±8.33)IU/L,t=8.188,P=0.039;观察组谷草转氨酶(aspartate aminotransferase,AST)水平为(92.04±9.31)IU/L,高于对照组的(85.33±8.14)IU/L,t=8.352,P=0.038;观察组白蛋白(albumin,ALB)水平为(31.17±5.11)g/L,低于对照组的(33.46±4.39)g/L,t=9.014,P=0.035;观察组甲胎蛋白(alpha fetoprotein,AFP)水平为(159.42±14.38)μg/L,低于对照组的(233.01±21.57)μg/L,t=10.846,P=0.029;观察组癌胚抗原(carcinoembryonic antigen,CEA)水平为(22.59±2.37)μg/L,低于对照组(25.18±3.26)μg/L,t=7.251,P=0.044;观察组糖类抗原(carbohydrate antigen19-9,CA19-9)水平为(135.74±12.88)ng/mL,低于对照组的(141.31±15.39)ng/mL,t=8.667,P=0.037。结论脾多肽注射液联合TACE可有效提高晚期肝癌患者临床治疗效果,改善患者肝功能指标,并降低肿瘤标志物水平。OBJECTIVE In recent years,the incidence of liver cancer has been increasing,and research on the treatment of patients with advanced liver cancer has been increasing.This study aims to analyze the clinical effect of spleen polypeptide injection combined with transcatheter arterial chemoembolization(TACE) on advanced liver cancer and its effect on liver function.METHODS A total of 108 patients with advanced liver cancer admitted to the Department of Interventional of Anyang Cancer Hospital from January 2015 to December 2017 were divided into control group(54 cases) and observation group(54 cases) according to matching method.The control group received routine TACE treatment,the observation group was treated with spleen polypeptide injection combined with TACE.The therapeutic effect,liver function index and tumor marker level were compared between the two groups.RESULTS The total effective rate of the observation group was 96.3%,which was higher than that of the control group(81.48%),χ^2=6.004,P=0.014.After treatment,the level of alanine aminotransferase(ALT) in the observation group was(75.13±7.58)IU/L,which was higher than that of the control group(73.01±8.33)IU/L,t=8.188,P=0.039.The level of aspartate aminotransferase(AST) in the observation group was(92.04±9.31)IU/L,which was higher than that of the control group(85.33±8.14)IU/L,t=8.352,P=0.038.The level of albumin(ALB) in the observation group was(31.17±5.11)g/L,which was lower than that of the control group(33.46±4.39)g/L,t=9.014,P=0.035.The level of alpha fetoprotein(AFP)in the observation group was(159.42±14.38)μg/L,which was lower than that of the control group(233.01±21.57)μg/L,t=10.846,P=0.029.The level of carcinoembryonic antigen(CEA) in the observation group was(22.59±2.37)μg/L,which was lower than that of the control group(25.18±3.26)μg/L,t=7.251,P=0.044.The level of carbohydrate antigen 19-9(CA19-9) in the observation group was(135.74±12.88)ng/ml,which was lower than that of the control group(141.31±15.39)ng/ml,t=8.667,P=0.037.CONCLUS

关 键 词：脾多肽注射液 经导管肝动脉化疗栓塞术 晚期肝癌 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]