调节性T细胞在脑出血后继发性损伤中的保护机制的研究进展  

Recent advance in protective mechanism of regulatory T cells in secondary injury of intracerebral hemorrhage

作　　者：朱慧敏 于继徐[2] 王念 王丽娟 车峰远[2] Zhu Huimin;Yu Jixu;Wang Nian;Wang Lijuan;Che Fengyuan(Graduate School, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China;Department of Neurology, Linyi People's Hospital, Linyi 276003, China;Neurological Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao 266003, China;Central Laboratory, Linyi People's Hospital, Linyi 276003, China)

机构地区：[1]山东第一医科大学(山东省医学科学院)研究生部,泰安271016 [2]临沂市人民医院神经内科,276003 [3]青岛大学附属医院神经重症监护室,青岛266003 [4]临沂市人民医院中心实验室,276003

出　　处：《中华神经医学杂志》2019年第5期501-506,共6页Chinese Journal of Neuromedicine

基　　金：山东省重点研发项目(2016GSF201056);临沂市科技发展计划(201717047).

摘　　要：脑出血是一种严重的急性脑血管疾病,而继发性损伤是脑出血后重要的损伤机制之一。目前研究证实调节性T细胞(Tregs)在脑出血后可以通过调节小胶质细胞亚型、抑制炎症反应等机制发挥其保护作用。笔者现围绕Tregs细胞在脑出血后继发性损伤中的保护机制的研究进展进行综述,以期为脑出血治疗中新的研究方向及治疗靶点的探索提供参考。Intracerebral hemorrhage (ICH) is a serious acute cerebrovascular disease, and secondary injury is one of the important mechanisms of injury after ICH. Studies have confirmed that regulatory T cells (Tregs) play important protective roles after ICH by modulating microglial phenotype and inhibiting inflammation, and other pathways. This article reviews the protective mechanism of Tregs in the secondary injury, in order to provide a new therapeutic target for ICH.

关 键 词：脑出血 继发性损伤 调节性T细胞 神经保护 

分 类 号：R743.34[医药卫生—神经病学与精神病学]