静脉溶栓后继发出血转化的发病机制及预测模型研究进展  

Advances in the pathogenesis and prediction models after intravenous thrombolysis secondary hemorrhagic transformation

作　　者：王彩玲[1] 冯娟[1] Wang Cailing;Feng Juan(Department of Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, China)

机构地区：[1]中国医科大学附属盛京医院神经内科

出　　处：《中国医师杂志》2019年第5期795-797,共3页Journal of Chinese Physician

摘　　要：静脉溶栓是治疗急性期脑梗死最有效的方法之一,然而溶栓后继发出血转化是其严重的并发症,现在多项研究表明低纤维蛋白血症和血脑屏障的严重破坏是导致这一结果的重要原因。溶栓后出血并非单一因素所致,国外对继发出血转化的预测研究模型较多,各种研究结果各有利弊,国内研究尚少,本文主要就静脉溶栓后继发出血转化的发病机制、分类及预测模型进行综述。Intravenous thrombolysis is one of the most effective methods for the treatment of acute cerebral infarction.However, secondary hemorrhagic transformation after thrombolysis is a serious complication.Many studies have shown that hypofibrinemia and severe damage to the blood-brain barrier are important causes of this result.Bleeding after thrombolysis is not caused by a single factor.Foreign countries have more predictive research models for hemorrhagic transformation.Various research results have their own advantages and disadvantage.Domestic research is still scarce.This article reviews the pathogenesis, classification and prediction models of hemorrhagic transformation after intravenous thrombolysis.

关 键 词：脑梗死 投药 静脉内 血栓溶解疗法 组织型纤溶酶原激活物 脑出血 模型 统计学 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]