戒毒人员干眼症个体化综合治疗效果  

Individualized comprehensive treatment for dry eye syndrome of drug addicts

作　　者：孙琰[1] 于文龙 哈建群 周哲[1] 高玉[1] 胡佳丽 SUN Yan;YU Wen-long;HA Jian-qun;ZHOU Zhe;GAO Yu;HU Jia-li(Department of Ophthalmology,the 411th Hospital of Chinese People's Liberation Army,Shanghai 200081,China)

机构地区：[1]中国人民解放军第四一一医院眼科,上海200081 [2]92435部队医院,福建宁德352103 [3]上海市高境强制隔离戒毒所,上海200439

出　　处：《中国临床研究》2019年第5期670-672,676,共4页Chinese Journal of Clinical Research

基　　金：上海市卫生和计划生育委员会科研课题(201640171)~~

摘　　要：目的探讨个体化综合治疗对戒毒人员干眼症的治疗方法和效果。方法选取2017年11月至2018年2月在上海市杨浦区某戒毒所强戒的干眼症患者106例,随机分为试验组和对照组,各53例。两组患者均给予玻璃酸钠滴眼液及普拉洛芬滴眼液联合应用,有睑板腺功能障碍者加用左氧氟沙星滴眼液。试验组对症支持治疗和增加护理干预、心理干预。观察治疗2周、治疗4周后,统计两组患者干眼症状评分、泪膜破裂时间(BUT)、泪液分泌试验Ⅰ(SIt Ⅰ)和角膜荧光素钠染色(FL)评分情况并比较。结果治疗前,两组干眼症状评分、BUT、SIt Ⅰ、FL评分比较均无统计学差异(P>0.05)。与治疗前相比,治疗第4周两组干眼症状评分、FL评分逐渐降低,BUT逐渐延长,SIt Ⅰ逐渐增加(P<0.05)。治疗第4周,试验组干眼症状评分和FL评分低于对照组(P<0.05)。治疗第2周、治疗第4周,试验组BUT均长于对照组,SIt Ⅰ均高于对照组(P<0.05,P<0.01)。结论滴眼液联合护理干预、心理干预和对症支持治疗,对于戒毒人员干眼症症状和体征有明显的改善作用。Objective To explore the therapeutic method and effect of individualized comprehensive treatment on dry eye syndrome of drug addicts.Methods A total of 106 patients with dry eye syndrome of drug addicts in drug rehabilitation center of Yangpu District of Shanghai from November 2018 to February 2017 were randomly divided into experimental group and control group(n= 53,each).All patients were treated with sodium hyaluronate eye drops and pralofen eye drops,and levofloxacin eye drops were added to patients with meibomian gland dysfunction(MGD).Nursing intervention,psychological intervention and symptomatic support therapy were given in experimental group.After 2-and 4-week of treatment,the dry eye symptom score,tear film breaking-up time(BUT),tear secretion test Ⅰ(SIt Ⅰ) and corneal fluorescein sodium staining(FL) score were observed and compared between two groups.Results Before treatment,there were no significant differences in dry eye symptom score,BUT,SIt I,FL score between two groups(all P>0.05).At 4-week after treatment,the dry eye symptom score and FL score gradually decreased,BUT gradually prolonged and SIt Ⅰ gradually increased in two groups(all P<0.05).At the 4th week of treatment,the dry eye symptom score and FL score in experimental group was significantly lower than that in control group(P<0.05).At the 2nd and 4th week of treatment,BUT prolonged,and SIt Ⅰ increased in experimental group significantly compared with control group(P<0.05,P<0.01).Conclusion Eye drops combined with nursing intervention,psychological intervention and symptomatic support therapy can obviously improve the symptoms and signs of drug addicts with dry eye syndrome.

关 键 词：干眼症 综合治疗 玻璃酸钠滴眼液 普拉洛芬滴眼液 角膜荧光素钠染色 

分 类 号：R777.34[医药卫生—眼科]