血府逐瘀汤联合常规治疗对急性脑梗死患者炎症反应、氧化应激、内皮及相关因子的影响  

Effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response,oxidative stress,endothelium and related factors in patients with acute cerebral infarction

作　　者：陈峰[1] 吴曦[1] 穆迎涛[1] 徐桃桃[1] 刘仁斌[1] CHEN Feng;WU Xi;MU Ying-tao;XU Tao-tao;LIU Ren-bin(Chinese Medical Center, Shiyan People's Hospital of Hubei Province, Shiyan, Hubei Province, 442000, China)

机构地区：[1]湖北省十堰市人民医院中医医学中心,湖北十堰442000

出　　处：《海南医学院学报》2019年第10期762-765,770,共5页Journal of Hainan Medical University

基　　金：十堰市2016科技局科学研究技术项目(16y50)~~

摘　　要：目的:探究血府逐瘀汤联合常规治疗对急性脑梗死患者炎症反应、氧化应激、内皮及相关因子的影响。方法:将本院收治的162例急性脑梗死患者随机分为对照组及观察组各81例。对照组采用降颅内压、抗凝、抗氧化及调脂等常规对症治疗,观察组在对照组基础上联合血府逐瘀汤治疗。比较分析两组炎症反应、氧化应激、内皮及相关因子的变化。结果:治疗前,两组肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、超氧化物歧化酶(SOD)、丙二醛(MDA)、晚期蛋白氧化产物(AOPPS)、内皮素-1(ET-1)、一氧化氮(NO)、基质金属蛋白酶(MMP-9)、血小板活化因子(PAF)、胰岛素样生长因子-1(IGF-1)水平比较,差异无统计学意义(P>0.05)。治疗后,两组TNF-α、CRP明显低于治疗前(P<0.05),且观察组TNF-α、CRP水平较对照组显著降低(P<0.05);两组MDA、AOPPS显著低于治疗前,而SOD显著高于治疗前(P<0.05),且观察组MDA、AOPPS显著低于对照组,而SOD明显高于对照组(P<0.05);两组ET-1明显低于治疗前,而NO明显高于治疗前(P<0.05),且观察组ET-1明显低于对照组,而NO明显高于对照组(P<0.05);两组MMP-9、PAF明显低于治疗前,而IGF-1显著高于治疗前(P<0.05),且观察组MMP-9、PAF明显低于对照组,而IGF-1明显高于对照组(P<0.05)。结论:血府逐瘀汤联合常规治疗急性脑梗死,可有效降低患者炎症及氧化应激反应,改善其血管内皮功能及神经功能,显著减轻脑损伤程度,具有临床推广意义。Objective: To explore the effects of Xuefu Zhuyu Decoction combined with conventional therapy on inflammatory response, oxidative stress, endothelium and related factors in patients with acute cerebral infarction. Methods: 162 patients with acute cerebral infarction admitted to our hospital from November 2016 to January 1818 were selected as subjects. According to the random sampling method, the subjects were divided into 81 cases in the control group and 81 cases in the observation group. The control group was treated with conventional intracranial pressure, anticoagulation, anti-oxidation and lipid-lowering treatment. The observation group was treated with Xuefu Zhuyu Decoction on the basis of the control group. The changes of inflammatory response, oxidative stress, endothelium and related factors were compared and analyzed. Results: Before treatment, the levels of TNF-α, CRP, SOD, MDA, AOPPS, NO, ET-1, MMP-9, PAF and IGF-1 in the two groups were not significantly different, and there was no statistical significance ( P >0.05). After treatment, the levels of TNF-α and CRP in the two groups were significantly lower than those before treatment ( P <0.05), and the levels of TNF-α and CRP in the observation group were significantly lower than control group ( P <0.05);the levels of MDA and AOPPS in the two groups were significantly lower than those before treatment ( P <0.05), while the level of SOD was significantly higher than before treatment ( P <0.05), and the levels of MDA and AOPPS in the observation group were significantly lower than control group ( P <0.05), while the level of SOD was significantly higher. In the control group ( P <0.05);the level of ET-1 in the two groups was significantly lower than that before treatment ( P <0.05), while the level of NO was significantly higher than that before the treatment ( P <0.05), and in the observation group the level of ET-1 was significantly lower than the control group ( P <0.05), while the level of NO was significantly higher. In the control group ( P <0.

关 键 词：血府逐瘀汤 常规治疗 急性脑梗死 炎症反应 氧化应激 内皮 相关因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]