不同碘营养地区哺乳妇女催乳素和雌二醇水平观察  

Observation of prolactin and estradiol levels in lactating women in different iodine nutrition areas

作　　者：金佰明 万思源 申红梅[2] 刘丽香[2] 孟凡刚[2] 张晓晔[2] Jin Baiming;Wan Siyuan;Shen Hongmei;Liu Lixiang;Meng Fangang;Zhang Xiaoye(Department of Preventive Medicine, School of Public Health, Qiqihar Medical College, Qiqihar 161006, China;Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China)

机构地区：[1]齐齐哈尔医学院公共卫生学院预防医学教研室,黑龙江齐齐哈尔161006 [2]哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所,150081

出　　处：《中华地方病学杂志》2019年第5期381-384,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81703175);国家自然科学基金面上项目(304150076).

摘　　要：目的观察不同碘营养地区哺乳妇女催乳素(PRL)、雌二醇(E2)水平变化。方法依据近年全国水源性高碘地区调查及全国碘缺乏病的监测结果,选择广西北海市南康镇、兴港镇和营盘镇(水碘≤10 μg/L,低碘地区),山西汾阳市阳城乡和贾家庄乡(水碘50~100 μg/L,适碘地区),山西汾阳市平遥县和冀村镇(水碘≥300 μg/L,高碘地区)作为调查点,收集3类地区哺乳妇女(n=100、97、123)的尿样及血样,采用砷铈催化分光光度法检测尿碘;采用化学发光免疫分析法测定血清PRL、E2水平。结果3类地区哺乳妇女尿碘中位数分别为51.42、283.62、842.31 μg/L,地区间比较差异有统计学意义(χ^2=241.09,P < 0.05);低碘地区的哺乳妇女处于碘营养缺乏状态(< 100 μg/L),适碘地区的哺乳妇女处于碘超适宜状态(200~299 μg/L),高碘地区的哺乳妇女处于碘过量状态(≥300 μg/L)。3类地区哺乳妇女血清PRL、E2中位数分别为38.81、20.98、16.41 μg/L和29.57、43.70、45.51 ng/L,地区间比较差异有统计学意义(χ^2=41.54、24.03,P均< 0.05)。Objective To observe prolactin (PRL) and estradiol (E2) levels in lactating women in different iodine nutrition areas. Methods According to the recent national water-borne high iodine area survey and the monitoring results of iodine deficiency disorders, the following places were selected, including Nankang, Xinggang and Yingpan towns of Beihai City, Guangxi (water iodine≤10 μg/L, low iodine areas), Yangcheng Township and Jiajiazhuang Township of Fenyang City, Shanxi (water iodine 50-100 μg/L, adaptive iodine areas), Pingyao County and Jicun Town of Fenyang City, Shanxi (water iodine ≥300 μg/L, high iodine areas), and urinary and blood samples were collected in lactating women (n=100, 97, 123) from the three regions. The urinary iodine concentration was tested by arsenic cerium catalytic spectrophotometry. Serum levels of PRL and E2 were determined by chemiluminescence immunoassay. Results The urinary iodine medians of lactating women were 51.42, 283.62, 842.31 μg/L, respectively, in the three regions, the difference between the regions was statistically significant (χ^2=241.09, P < 0.05);the iodine levels of lactating women in low iodine areas, adaptive iodine areas and high iodine areas were in the state of iodine deficiency (< 100 μg/L), sufficient or adequate (200-299 μg/L) and iodine excess status (≥300 μg/L), respectively. Serum PRL and E2 levels of lactating women in the three types of areas were 38.81, 20.98, 16.41 μg/L and 29.57, 43.70, 45.51 ng/L, respectively. The differences between the regions were statistically significant (χ^2=41.54, 24.03, P < 0.05). Conclusion With the increase of iodine nutrition level, PRL in lactating women has presented a gradually decreasing trend, E2 is increased.

关 键 词：碘 哺乳妇女 催乳素 雌二醇 

分 类 号：R153.1[医药卫生—营养与食品卫生学]