硫糖铝联合泮托拉唑治疗消化性溃疡并发出血安全性与有效性分析  

Safety and efficacy of sucralfate combined with pantoprazole in the treatment of peptic ulcer complicated by hemorrhage

作　　者：王军杰 WANG Junjie(Department of Internal Medicine, Jiulong Health Center, Zhengzhou Economic and Technological Development Zone, Zhengzhou 450000, Hvince Province, China)

机构地区：[1]郑州经济技术开发区九龙卫生院内科

出　　处：《西南医科大学学报》2019年第3期257-260,共4页Journal of Southwest Medical University

摘　　要：目的:研究硫糖铝联合泮托拉唑治疗消化性溃疡并发出血的安全性与有效性评价。方法:选择2017年5月至2018年4月在我院接受治疗的消化性溃疡并发出血的102例患者进行研究。以随机数字表法将患者分为2组,各51例。两组患者均给予硫糖铝及云南白药常规治疗,对照组加以奥美拉唑,观察组加以泮托拉唑。对比两组患者止血效果、溃疡治疗效果、血清表皮生长因子水平、治疗后Forrest分级Ⅲ级比例及安全性。结果:观察组止血有效率为90.20%,明显高于对照组的72.55%(P<0.05)。观察组溃疡治疗有效率为88.23%,明显高于对照组的68.63%(P<0.05)。两组干预后血管内皮生长因子水平均明显上升,但观察组上升幅度更为明显(P<0.05)。两组干预后Forrest分级Ⅲ级比例均明显上升,但观察组上升幅度更为明显(P<0.05)。两组患者治疗前后三大常规及肝肾功能实验室指标均未出现明显变化。对照组出现疑似因药物不良反应3例(5.88%),包括皮肤瘙痒1例、便秘1例、心悸1例,均经停药或降低使用量对症处理后得到控制。观察组未见明显药物不良反应(0.00%),两组对比差异无统计学意义(P>0.05)。结论:硫糖铝联合泮托拉唑较奥美拉唑可明显提高止血、溃疡治疗效果、提高血清表皮生长因子水平、提高Forrest分级Ⅲ级比例、不增加不良反应发生率。Objective: To evaluate the safety and efficacy of sucralfate combined with pantoprazole in the treatment of peptic ulcer complicated by hemorrhage. Methods: A total of 102 patients who received treatment for peptic ulcer complicated by hemorrhage in our hospital between May 2017 to April 2018 were enrolled in this study. Patients were divided into two groups (n = 51 per group) using the random number table method. In addition to the conventional sucralfate and Yunnan Baiyao treatment in both groups, the control group was given omeprazole and the observation group was given pantoprazole. Treatment efficacy on hemostasis and ulcer, serum epidermal growth factor level, proportion of post-treatment Forrest grade Ⅲ cases, and safety were compared between the two groups. Results: The effective rate of hemostasis was significantly higher in the observation group than in the control group (90.20% vs 72.55%, P < 0.05). The effective rate of ulcer treatment was also significantly higher in the observation group than in the control group (88.23% vs 68.63%, P < 0.05). Vascular endothelial growth factor levels and the proportion of Forrest grade Ⅲ cases were significantly increased after intervention in both groups, but the magnitude of increase was greater in the observation group (all P < 0.05). There were no significant changes in the three routine test parameters and liver and kidney function parameters after treatment. Three cases (5.88%) of suspected adverse drug reactions were observed in the control group, including 1 case of skin itching, 1 case of constipation, and 1 case of heart palpitations. All of these reactions were controlled after drug termination or dose reduction. No significant adverse drug reaction (0.00%) was observed in the observation group. There was no significant difference in the incidence rate of adverse drug reactions between the two groups (P > 0.05). Conclusion: Compared with omeprazole, sucralfate combined with omeprazole has significantly improved treatment efficacy on hemostasis and ulc

关 键 词：硫糖铝 泮托拉唑 消化性溃疡并发出血 安全性 有效性 

分 类 号：R573[医药卫生—消化系统]