DNA异常甲基化在恶性肿瘤发生中的作用及其在卵巢癌中的研究进展  

The Role of DNA Aberrant Methylation in Malignant Tumorigenesis and Its Research Progress in Ovarian Cancer

作　　者：闫冰冰 YAN Bing-bing(Department of Women's Health,Guangxi Maternal and Child Health Hospital,Nanning,Guangxi,530000 China)

机构地区：[1]广西壮族自治区妇幼保健院妇女保健部

出　　处：《中外医疗》2019年第11期196-198,共3页China & Foreign Medical Treatment

摘　　要：近年来受多方面因素影响,各类恶性肿瘤疾病发病率均呈现不断上升趋势,对患者生活质量及生命健康均造成严重威胁。恶性肿瘤疾病的发生已确定与多种分子改变有关,表观遗传学改变与机体多种肿瘤疾病的出现存在着密切联系,肿瘤抑制基因的DNA甲基化是恶性肿瘤发病过程中常见的表观遗传学现象,与肿瘤发生、发展均具有一定的相关性。以往,临床已明确DNA甲基化属于基因表现遗传调控的重要方式之一,但就DNA异常甲基化在恶性肿瘤发生中的具体作用的相关报道较少,该文主要就DNA异常甲基化在恶性肿瘤发生中的作用及其在卵巢癌中的研究进展进行分析,从而为卵巢癌等恶性肿瘤的早期诊断、治疗及病情进展程度的鉴别提供方法参考。In recent years, due to various factors, the incidence of various malignant tumor diseases has been on the rise, which poses a serious threat to the quality of life and health of patients. The occurrence of malignant tumor diseases has been determined to be related to a variety of molecular changes. Epigenetic changes are closely related to the emergence of various tumor diseases in the body. DNA methylation of tumor suppressor genes is a common appearance in the pathogenesis of malignant tumors. Genetic phenomena have a certain correlation with tumorigenesis and development. In the past, it has been well established that DNA methylation is one of the important ways of genetic regulation of gene expression. However, there are few reports on the specific role of DNA aberrant methylation in malignant tumorigenesis. The role of malignant tumors and its research progress in ovarian cancer are analyzed, which provides a reference for the early diagnosis, treatment and differentiation of malignant tumors such as ovarian cancer.

关 键 词：DNA甲基化 恶性肿瘤 卵巢癌 抑制基因 蛋白质 

分 类 号：R737[医药卫生—肿瘤]