应用药物利用研究理论对精神分裂症临床用药的再评价研究  

Revaluation of clinical drugs for schizophrenia using drug utilization research theory

作　　者：张铮 薄纯光[2] 李红彩[2] 周超[3] 邱炳杰 韩攸村 ZHANG Zheng;BO Chunguang;LI Hongcai(Binzhou Youfu Hospital, Binzhou,256603, China)

机构地区：[1]滨州市优抚医院,山东滨州256603 [2]滨州职业学院 [3]滨州医学院附属医院

出　　处：《精神医学杂志》2018年第6期428-430,共3页Journal of Psychiatry

基　　金：2019年度滨州市社会科学规划重点研究课题(编号:19-SKGH-20);2018年度滨州市科学技术发展计划(软科学部分)立项课题(编号:2018BRK30)

摘　　要：目的应用药物利用研究(DUR)理论,对精神分裂症患者临床用药的合理性与安全性进行再评价。方法对滨州市某精神病专科医院2018年度精神分裂症患者临床用药情况进行病历回顾性分析,利用药物研究理论探讨精神分裂症临床常用药物应用合理性与安全性。结果奥氮平片的DUR分析结果均较高,提示可能存在用药处方剂量过大或药物滥用情况,应加强临床用药监测;富马酸喹硫平片和利培酮片全年DUR波动分析正常,未出现异常结果。同时可对重点月份处方进行回顾性分析,防止超剂量或药物滥用情况的产生。结论应用药物利用研究理论可真实、准确地反应精神分裂症患者的临床用药情况,有效增加药物安全性和应用合理性,可达到增强临床治疗效果和控制不良反应的目的。Objective To revalue the rationality and safety of clinical drug application in schizophrenia by applying the theory of drug utilization research(DUR). Methods Medical records of clinical drugs used in patients with schizophrenia in 2018 in Binzhou psychiatric hospital were retrospectively analyzed and the rationality and safety of drug application were explored by DUR. Results,The results of DUR analysis of olanzapine tablets were high. This suggested that the olanzapine tablets may be over-dosed or abused, and thus clinical drug monitoring should be strengthened. The DUR fluctuation analyses of quetiapine fumarate tablets and risperidone tablets were normal. At the same time, retrospective analyses of the prescriptions in key months could be conducted to prevent over-dosing or drug abuse. ConclusionThe application of DUR can reflect the clinical drug use in schizophrenics accurately, to increase the safety and rationality of drug application, and helps to achieve the purposes of enhancing treatment effect and controlling adverse reactions.

关 键 词：药物利用研究 精神分裂症 合理性 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]