阿司匹林联合氯吡格雷在急性高危非致残性缺血性脑血管病治疗中的应用研究  

Clinical efficacy of aspirin combined with clopidogrel in the treatment of acute HR-NICE

作　　者：樊朝军 杨源瑞 魏俊[3] 雷琼[1] FAN Chaojun;YANG Yuanrui;WEI Jun;LEI Qiong(Department of Neurology,Yibin People′s Hospital,Yibin,Sichuan 644600,China;Cadre Ward,General Hospital of Chengdu Military Region,Chengdu,Sichuan 610083,China;Department of Neurology,Yibin First People′s Hospital,Yibin,Sichuan 644000,China)

机构地区：[1]宜宾县人民医院神经内科,四川宜宾644600 [2]成都军区总医院干部病房,四川成都610083 [3]宜宾市第一人民医院神经内科,四川宜宾644000

出　　处：《现代医药卫生》2019年第11期1622-1624,共3页Journal of Modern Medicine & Health

基　　金：四川省宜宾市卫生健康委员会科研项目(2016-08)

摘　　要：目的研究氯吡格雷联合阿司匹林治疗急性高危非致残性缺血性脑血管病(HR-NICE)的疗效及安全性。方法将急性HR-NICE患者随机分为阿司匹林组(160例)和阿司匹林、氯吡格雷联合治疗组(198例),分别给予药物治疗。比较两组患者临床疗效,治疗前后凝血指标水平,以及并发症发生情况。结果联合治疗组治疗总有效率为87.87%,高于阿司匹林组(71.87%,P<0.05),联合治疗组与阿司匹林组治疗前后血小板、活化部分凝血酶时间及凝血酶原时间水平比较差异无统计学意义(P>0.05)。治疗期间,两组患者并发症发生率比较差异无统计学意义(P>0.05)。结论氯吡格雷联合阿司匹林治疗急性HR-NICE,疗效较佳、安全性高,可推广应用。Objective To observe the clinical efficacy and safety of clopidogrel combined with aspirin in the treatment of acute high risk non-ischemic ischemic cerebrovascular events(HR-NICE). Methods Patients with acute HR-NICE were randomly divided into aspirin group(160 cases) and aspirin combined with clopidogrel group(198 cases).The clinical efficacy,coagulation parameters and adverse reactions of the two groups before and after treatment were observed and compared. Results After treatment,the total effective rate of aspirin combined with clopidogrel group was 87.87%,higher than the 71.87% of aspirin group( P < 0.05 ).There was no significant differences in the levels of platelet,prothrombin time and activated partial thromboplastin time between the combined treatment group and the aspirin group( P >0.05).During treatment,there was no significant difference in the incidence of complications between the two groups( P >0.05). Conclusion Clopidogrel combined with aspirin could be effective and safe in the treatment of acute HR-NICE.

关 键 词：氯吡格雷 阿司匹林 急性高危非致残性缺血性脑血管事件 

分 类 号：R743.3[医药卫生—神经病学与精神病学]