噬菌体裂解酶的应用概况  

The application profile of bacteriophage lysins

作　　者：严晶 胡申才[1] YAN Jing;HU Shen-cai(School of Biological and Pharmaceutical Engineering,Wuhan Polytechnic University,Wuhan 430023,China)

机构地区：[1]武汉轻工大学生物制药工程学院

出　　处：《湖北农业科学》2019年第10期5-8,50,共5页Hubei Agricultural Sciences

摘　　要：近年来由于耐药菌的频频出现,抗生素在抗感染领域面临前所未有的挑战,目前研制可裂解病原菌的噬菌体制剂已为一大热点。噬菌体裂解酶是双链DNA噬菌体在基因组复制晚期合成的一类蛋白质,它能够水解细菌细胞壁中的肽聚糖从而杀灭细菌。噬菌体裂解酶在体内外的试验中都表现出很高的杀菌性、种属特异性和安全性,因而具有广阔的应用前景。简要介绍了噬菌体裂解酶的结构性质,并对裂解酶显示出的抗菌性能及应用进行了综述。More recently, the original application of phage as therapeutics to treat human and animal infections has been rekindled, particularly in an era where antibiotic resistance has become so problematic. Bacteriophage lysins,which are peptidoglycan hydrolases encoded by double-stranded DNA bacteriophage, are produced in phage-infected bacterial cells toward the end of the lytic cycle. It was proved that the phage lysins exhibited high activity against bacteria, narrow antibacterial spectrum, and apparent safety in vitro and vivo experiments. Those paved solid foundation for further exploration of their application. A review on the structure and mode of action of lysins and their application were presented.

关 键 词：噬菌体 裂解酶 耐药菌 

分 类 号：S562[农业科学—作物学]