正交法优化ZnO/MMT抗菌材料制备条件及抑菌活性研究  

Optimization on Preparation Condition and Antibacterial Properties of ZnO/MMT Antibacterial Materials with the Orthogonal Test

作　　者：麻晓霞[1] 高灵娟 马玉龙[1] 翟喜会 杨青萍 马春香 MA Xiao-xia;GAO Ling-juan;MA Yu-long;ZHAI Xi-hui;YANG Qing-Ping;MA Chun-xiang(State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering,Collage of Chemistry and Chemical Engineering,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏大学化学化工学院省部共建煤炭高效利用与绿色化工国家重点实验室

出　　处：《人工晶体学报》2019年第5期928-932,967,共6页Journal of Synthetic Crystals

基　　金：国家自然科学基金(51564043);宁夏自然科学基金(2019AAC03019)

摘　　要：以氯化锌、氢氧化钠为原料,蒙脱石(Montmorillonite,MMT)为载体,最小抑菌浓度(MIC)和最小杀菌浓度(MBC)为测试指标,采用正交试验考察物料配比、反应温度、反应时间等因素对该抗菌材料抑菌活性的影响,确定ZnO/MMT抗菌材料的最佳制备条件,并通过XRD、SEM和BET对其结构进行了表征。结果表明,影响该抗菌材料性能的因素依次为反应温度>物料配比>反应时间,制备ZnO/MMT抗菌材料的最佳条件为氯化锌∶氢氧化钠=1∶8,反应温度为70℃,反应时间为18h。ZnO/MMT抗菌材料对沙门氏菌(Salmonella)、大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)具有广谱抗菌性。The antibacterial material ZnO/MMT was synthesized with zinc chloride and sodium hydroxide as raw materials and montmorillonite(MMT) as carrier,which was characterized by XRD,SEM and BET. The optimum preparation conditions of ZnO/MMT,such as material ratio,reaction temperature and reaction time,were investigated by orthogonal test with the indexes of minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC). The results showed that the sequences of influencing factors are reaction temperature > material ratio > reaction time. The optimal preparation conditions of ZnO/MMT are as follows,zinc chloride∶ sodium hydroxide =1∶ 8,the reaction temperature at 70 ℃ and the reaction time for 18 h. What’s more,ZnO/MMT has a broad spectrum of antimicrobial activity against Salmonella , E.coli and S. aureus .

关 键 词：抗菌材料 氧化锌 蒙脱石 制备条件 抑菌活性 

分 类 号：TG174.1[金属学及工艺—金属表面处理]