肌酐检测方法学评价及其研究进展  

Methodological Evaluation for Determination of Creatinine in Serum and Its Development

作　　者：谭红军[1] 罗春华[2] 杨林[1] 董贞荣 张玉红 张新明[1] 汪彬彬[3] TAN Hong-jun;LUO Chun-hua;YANG Lin;DONG Zhen-rong;ZHANG Yu-hong;ZHANG Xin-ming;WANG Bin-bin(Department of Medicine,Hubei Three Gorges Vocational and Technical College,Yichang,Hubei Province,443000 China;The First Clinical Medical College of Three Gorges University,Yichang,Hubei Province,443003 China;Affiliated Hospital of Hubei Three Gorges Vocational and Technical College,Yichang,Hubei Province,443000 China)

机构地区：[1]湖北三峡职业技术学院医学院,湖北宜昌443000 [2]三峡大学第一临床医学院,湖北宜昌443003 [3]湖北三峡职业技术学院附属医院,湖北宜昌443000

出　　处：《系统医学》2019年第8期191-194,共4页Systems Medicine

基　　金：湖北三峡职业技术学院立项课题(2017KY09)

摘　　要：描述肌酐检测在临床疾病诊断上的价值,肌酐检测方法有Jaffe反应法、硫酸铜肌酐复合物氧化Metol光度法、酶法、化学发光法与荧光匀相法、毛细管电泳法、拉曼散射法、电极法、高效液相色谱法、同位素稀释质谱法等。其中部分方法目前未见有系统评价,临床上因方法学和其他各类原因导致肌酐检测结果存在明显差异,该文较全面地综述了肌酐检测的方法学评价及研究进展。Creatinine is one of the most important clinical biomarkers.Its measurement is based on the Jaffe method,copper sulfate creatinine complex oxidation metol photometry,enzymatic assays,chemiluminescence method and fluorescence homogenization method,capillary electrophoresis,Raman scattering method,electrode method,high performance liquid chromatography and isotope dilution mass spectrometry.There are significant differences in creatinine test results due to methodological and other reasons.In this paper reviews the methodological evaluation and their development of creatinine test.

关 键 词：肌酐 Jaffe反应 酶法 方法学评价 

分 类 号：R446.1[医药卫生—诊断学]