408例结直肠癌术后患者Cox模型的生存分析  

Survival Analysis of Cox Model in 408 Patients with Colorectal Cancer after Operation

作　　者：武雪亮[1] 王立坤[1] 黄先涛[1] 韩磊[1] 孙光源 史永兴 袁泽龙 范爽 杨东东[1] 屈明[1] 薛军[1] Wu Xueliang;Wang Likun;Huang Xiantao;Han Lei;Sun Guangyuan;Shi Yongxing;Yuan Zelong;Fan Shuang;Yang Dongdong;Qu Ming;Xue Jun(rfhe First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China)

机构地区：[1]河北北方学院附属第一医院,河北省张家口市075000

出　　处：《中国病案》2019年第4期45-48,共4页Chinese Medical Record

基　　金：河北省卫计委医学科学研究重点课题计划(NO 20180834)

摘　　要：目的分析结直肠癌患者术后的生存时间,探讨其预后的相关影响因素。方法随机抽取2011年1月-2013年12月河北某三甲医院425例行手术治疗且病理确诊为结直肠癌的患者,对其年龄、性别、饮食习惯、分化程度、病理类型等临床资料进行总结,统计其生存期,将所有信息校对无误后应用Cox风险比例模型分析。结果 425例患者中,408例患者获完整随访,失访率为4.0%,随访4个月-95个月,平均55.0个月,1年、3年和5年总生存率分别为90.20%、72.44%和55.47%;单因素分析结果显示:年龄、性别、饮食习惯、分化程度、病理类型、浸润深度、淋巴结转移、TNM分期、手术方式与本地区结直肠癌患者生存时间均相关(P<0.05),而吸烟、病变直径、术前处理等与生存时间均无关(P>0.05);Cox模型预后生存分析结果显示:TNM分期、手术方式、病理类型、淋巴结转移、分化程度、饮食习惯、年龄均是本地区结直肠癌患者预后的重要因素(P<0.05)。结论 TNM分期、手术方式、饮食习惯是影响本地区结直肠癌患者预后的重要因素,加强科普宣传、建立健康的饮食方式、早期筛查诊断、行根治性手术,有利于延长结直肠癌患者生存期。Objective To discuss the survival time of postoperative patient with colorectal cancer and analyze the influencing factors of those patients’ prognosis. Methods 425 patients diagnosed with colorectal cancer treated by operation were randomly selected during January 2011 to December 2013 in a Three Grade Hospital of HeBei province.The age,gender,dietary habits,differentiation degree,pathological types and other clinical data of the patients were summarized,and their survival time was recorded.Cox proportional risk model was used to analyze all information after all information was checked correctly. Results Among the 425 cases, 408 of them were followed-up for 4-95 months(55.0 months avg) and the missing rate is 4.0%. Survival rate for 1,3 and 5 years were 90.20%, 72.44%and 55.47%. Single factor analysis showed that age, gender, dietary habit, differentiated degree, pathology types, depth of invasion, lymphatic metastasis, TNM staging and operation methods were relevant to the survival time of the patients with colorectal cancer in this area, P<0.05, while irrelevant factors were smoking, diameter of tumor, preparation for operation etc, P>0.05. Cox model showed that TNM staging,operation methods), pathology types, lymphatic metastasis, differentiated degree, dietary habit, age were important factors to the prognosis of the patients. Conclusion TNM staging, operation methods and dietary habit are important factors which influence the prognosis of the patients with colorectal cancer in this area. It can improve survival to strengthen popularization of science, build a healthy diet, early screening and diagnosis and have radical surgery.

关 键 词：结直肠癌 生存时间 COX风险模型 预后因素 

分 类 号：R735.34[医药卫生—肿瘤]