抗Hu、Yo抗体双重阳性副肿瘤性边缘叶脑炎一例  

Paraneoplastic limbic encephalitis with double positive anti-Hu and Yo antibodies:a case report

作　　者：耿延磊[1] 陈金波[1] 马贺[1] 陈宏亮[1] 宋晓文[1] 李红[1] 鹿树军[1] 苏毅鹏[1] 胡耀芝 李聪 耿学川[3] Geng Yanlei;Chen Jinbo;Ma He;Chen Hongliang;Song Xiaowen;Li Hong;Lu Shujun;Su Yipeng;Hu Yaozhi;Li Cong;Geng Xuechuan(Department of Neurology,Binzhou Medical University Hospital,Binzhou,Shandong 256603,China;Department of Neurology,Shengli Oilfield Central Hospital,Dongying,Shandong 257000,China;Department of Neurology,Boxing County People's Hospital,Binzhou,Shandong 256500,China)

机构地区：[1]滨州医学院附属医院神经内科,山东滨州256603 [2]胜利油田中心医院神经内科,山东东营257000 [3]博兴县人民医院神经内科,山东滨州256500

出　　处：《中华神经科杂志》2019年第5期406-409,共4页Chinese Journal of Neurology

摘　　要：神经系统副肿瘤综合征是一组与肿瘤相关的影响中枢神经和外周神经肌肉系统的罕见的自身免疫性疾病,如累及大脑边缘叶系统则表现为副肿瘤性边缘叶脑炎。早期识别神经系统副肿瘤综合征患者有一定困难,因为导致副肿瘤性神经系统疾病的肿瘤常常无症状或隐匿,且单次相关抗体检测可能出现假阴性。在此,我们报道1例抗Hu、Yo抗体双重阳性的副肿瘤性边缘叶脑炎患者,并结合相关文献进一步分析讨论,以提高对该病的认识。Paraneoplastic neurological syndromes (PNS) are a rare group of immune-mediated disorders that affect the central and peripheral neuromuscular system in association with cancer. If the limbal lobe system of the brain is involved, it will show paraneoplastic limbal encephalitis (PLE).The discern of patients with PNS is challenging since tumors causing paraneoplastic neurologic disorders are often asymptomatic and sometimes occult. We report a case of PLE with double positive anti-Hu and Yo antibodies, and further analyze and discuss it in conmbination with relevant literature to improve the understanding of the disease.

关 键 词：副肿瘤综合征 神经系统 边缘叶脑炎 自身抗体 

分 类 号：R742.9[医药卫生—神经病学与精神病学]