非小细胞肺癌锌指蛋白217的表达及其临床意义  

Expression of zinc finger protein 217 in non-small cell lung cancer and its clinical significance

作　　者：常世川[1] 冉文华[1] 罗贤琴 张卜娟 刘良忠[1] Chang Shichuan;Ran Wenhua;Luo Xianqin;Zhang Bujuan;Liu Liangzhong(Department of Oncology, Chongqing Three Gorges Central Hospital, Chongqing 404000, China)

机构地区：[1]重庆三峡中心医院肿瘤科,404000

出　　处：《肿瘤研究与临床》2019年第5期310-314,共5页Cancer Research and Clinic

摘　　要：目的探讨锌指蛋白217(ZNF217)在非小细胞肺癌(NSCLC)中的表达及其与患者预后的关系。方法选择2012年1月至2013年10月重庆三峡中心医院收治的120例NSCLC患者。采用免疫组织化学方法检测ZNF217在NSCLC组织及癌旁组织中的表达,分析ZNF217的表达与患者临床病理特征的相关性;采用Kaplan-Meier法及Cox回归模型多因素分析法,探讨影响NSCLC根治术预后的因素。结果ZNF217主要表达于肿瘤细胞核内,肿瘤组织的ZNF217阳性率高于癌旁组织[52.5%(63/120)比20.1%(25/120);χ^2=25.909,P<0.05]。随着肿瘤T分期(χ^2=7.333,P=0.026)、N分期(χ^2=7.782,P=0.020)、TNM分期(χ^2=11.557,P=0.003)的升高,ZNF217阳性率增高。ZNF217阳性患者术后总生存(P=0.007)及无进展生存(P=0.004)较阴性患者差。Cox多因素分析显示,ZNF217是影响NSCLC预后的独立危险因素。结论ZNF217是影响NSCLC预后的独立危险因素,可能成为NSCLC精准治疗的潜在靶点。Objective To explore the expression of zinc finger protein 217 (ZNF217) in non-small cell lung cancer (NSCLC) and its correlation with prognosis of patients. Methods A total of 120 NSCLC patients in Chongqing Three Gorges Central Hospital from January 2012 to October 2013 were selected. Immunohistochemical method was used to test the expression of ZNF217 in NSCLC tissues and paracancerous tissues. The correlation of ZNF217 expression with patient's clinicopathological features was analyzed. At the same time, the Kaplan-Meier method and Cox regression model multiple factor analysis method were used to explore the factors affecting the prognosis of patients after NSCLC radical operations. Results ZNF217 mainly existed in cell nucleus of NSCLC. The positive expression rate of ZNF217 in the cancer tissues was higher than that in the paracancerous tissues [52.5%(63/120) vs. 20.1%(25/120),χ2= 25.909, P < 0.05]. The positive expression rate of ZNF217 increased with the increase of tumor T stage (χ^2= 7.333, P= 0.026), N stage (χ^2= 7.782, P= 0.020) and TNM stage (χ^2= 11.557, P= 0.003). The overall survival (P= 0.007) and progression-free survival (P= 0.004) of patients with positive ZNF217 were poorer than those of patients with negative ZNF217. Cox multiple factor analysis showed that ZNF217 was an independent risk factor affecting the prognosis of NSCLC. Conclusion ZNF217 is an independent risk factor affecting the prognosis of NSCLC, and it may be a potential target for accurate treatment of NSCLC.

关 键 词：癌 非小细胞肺 锌指蛋白217 预后 

分 类 号：R734.2[医药卫生—肿瘤]