腐植酸抗肿瘤作用机制的研究进展  

Progress of antitumor mechanisms of humic acids

作　　者：辛鹏飞 张彩凤 刘青梅[1] Xin Pengfei;Zhang Caifeng;Liu Qingmei(Department of Stomatology, Shanxi Academy of Medical Sciences, Shanxi Dayi Hospital, Taiyuan 030032, China;Department of Chemistry, Taiyuan Normal University, Humic Acid Engineering and Technology Research Center of Shanxi Province, Jinzhong 030619, China)

机构地区：[1]山西医学科学院山西大医院口腔科,太原030032 [2]太原师范学院化学系山西省腐植酸工程技术研究中心,晋中030619

出　　处：《肿瘤研究与临床》2019年第5期357-360,共4页Cancer Research and Clinic

基　　金：山西省卫生健康委科研课题(2018017);山西省“1331工程”协同创新中心建设计划经费;量子光学与光量子器件国家重点实验室(山西大学)开放课题(KF201604).

摘　　要：腐植酸是一类天然大分子有机弱酸混合物,包含有较多活性基团如醌基、酚基、羧基、羟基、芳环等结构。不同的芳香结构和活性基团对生物体可能存在不同的反应及药理作用。近年来的研究表明,腐植酸类物质可能从激活免疫系统、诱导细胞损伤及细胞凋亡、发挥光热转换或络合其他材料来发挥抗肿瘤作用。现就腐植酸类物质抗肿瘤作用机制的研究进行综述。Humic acids, a complex macromolecular organic carbon resources, contain different functional groups such as quinones, phenols, carboxylic acids, hydroxyl, and aromatic structures. The various functions and pharmacological activities are mainly attributable to the different functional groups of humic acids. In recent years, studies show that antitumor effect of humic acids can be analyzed from activation of immune system, induction of cell injury and apoptosis, photothermal reaction, or binding with other materials. This paper reviews the progress of antitumor mechanisms of humic acids.

关 键 词：肿瘤 腐植酸 光热治疗 诊疗制剂 

分 类 号：R73-36[医药卫生—肿瘤]