UPDRS评分对帕金森病临床疗效的影响因素分析  

Analysis of Factors Affecting the Therapeutic Effect on Parkinson’s Disease Based on UPDRS Score

作　　者：张淑琴[1] 吴丹[1] 欧阳存[1] 魏进[1] Zhang Shuqin;Wu Dan;Ouyang Cun;Wei Jin(Department of Neurology, the Affiliated Hospital of Jianghan University, Wuhan 430015 , China)

机构地区：[1]江汉大学附属医院神经内科

出　　处：《国际老年医学杂志》2019年第3期137-139,146,共4页International Journal of Geriatrics

基　　金：武汉市卫生和计划生育委员会基金项目(WG16D02)

摘　　要：目的 探究统一帕金森评定量表(UPDRS)评分对帕金森病(PD)临床疗效的影响因素.方法 回顾性分析我院2014年10月~2017年2月间收治的PD患者216例,采用多中心、单盲、随机问卷的调查模式,统计患者发病年龄、受教育年限、不和谐家庭关系、用药情况、治疗时间间隔、运动情况、合并PD非运动症状等非药物因素,由未参与诊疗的神经专科医师进行UPDRS评分,根据治疗后UPDRS评分分为≤50分组和>50分组,比较两组患者的非药物影响因素,多因素logistic回归分析各因素对患者UPDRS评分影响.结果 UPDRS评分≤50分组的发病年龄、治疗时间间隔及不和谐家庭关系和合并PD非运动症状比例均明显低于UPDRS评分>50分组(P<0.05),受教育年限、规范化用药和规律运动比例均明显高于UPDRS评分>50分组(P<0.05);多因素logistic回归分析显示,发病年龄、受教育年限、不和谐家庭关系、用药情况、治疗时间间隔、运动情况及合并PD非运动症状均是UPDRS评分独立影响因素(P<0.05).结论 年龄增加、受教育年限较低、家庭情况欠佳、用药不规范、治疗时间间隔过长、缺乏运动及合并PD非运动症状等均是治疗PD临床疗效的影响因素,临床治疗过程中,应积极避免非药物影响因素,有助于提高疗效.Objective To explore the factors affecting the therapeutic effect on Parkinsons disease ( PD) based on Unified Parkinsons Disease Rating Scale ( UPDRS) score. Methods 216 patients with PD between October 2014 and February 2017 were enrolled. The multi-center, single-blind and randomized questionnaire was used to investigate the non-drug factors, such as age of onset, length of education, family relationship, medication, treatment interval, exercise, and non-motor symptoms of PD. The patients were assessed with UPDRS by neurologists who were not involved in the diagnosis and treatment. The patients were divided into the group with UPDRS score ≤50 and the group with UPDRS score >50 according to the UPDRS score. The non-drug factors between the two groups were evaluated. Logistic regression analysis was performed to analyze the factors influencing the UPDRS score. Results The age of onset, treatment interval, the proportion of disharmonious family relationships and non-motor symptoms of PD in the group with UPDRS score W50 were significantly lower than those in the group with UPDRS score >50 ( P<0.05). The length of education, the proportion of standardized medication and regular exercise were significantly higher in the group with UPDRS score W 50 than those in the group with UPDRS score>50 ( P<0.05). Logistic regression analysis showed that the age of onset, length of education, disharmonious family relations, medication, treatment interval, exercise and appearance of non-motor symptoms of PD were independent factors for UPDRS score ( P<0.05 ). Conclusion The increase of age, low education level, poor family relationship, non- standardized medication, and long treatment interval, lack of exercise and appearance of non-motor symptoms are the factors which affect the therapeutic effect in the treatment of PD. Avoiding non-drug factors may improve the therapeutic efficacy.

关 键 词：UPDRS评分 帕金森病 疗效 影响因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]