老年女性乳腺癌临床病理特征、治疗方式及预后的临床研究  

Clinicopathological features,treatment and prognosis of breast cancer in elderly women

作　　者：刘庆伟[1] Liu Qing-wei(People's Hospital of Jurong City,Jurong 212400,China)

机构地区：[1]句容市人民医院

出　　处：《牡丹江医学院学报》2019年第3期70-73,共4页Journal of Mudanjiang Medical University

摘　　要：目的 探讨分析老年女性乳腺癌临床病理特征、治疗方式及预后。方法 选择2010年4月至2015年7月我院收治的≥65岁老年乳腺癌患者95例,采用免疫组织化学法检测组织标本雌激素受体(ER)、孕激素受体(PR)表达情况,采用免疫组织化学法或荧光原位杂交法判断患者组织人表皮生长因子受体-2(HER-2)表达情况。分析95例患者临床病理特征、治疗方式及其预后情况,并分析不同因素对患者预后的影响。结果 95例老年乳腺癌患者中,病理类型主要为浸润性导管癌74.74%(71/95),肿瘤直径主要为T2(2~5cm)64.21%(61/95)、淋巴结转移占28.42(27/95);远处转移占7.37%(7/95)分子分型主要为LuminalA型47.37%(45/95)。95例老年乳腺癌患者中,其中90例患者选择乳腺全切术治疗,5例患者采取保乳治疗;60.00%(57/95)患者术后均选择内分泌治疗方案,48.42%(46/95)患者选择化疗治疗,21.05%(20/95)患者选择放射治疗。对可能影响老年乳腺癌患者生存预后的各因素进行单因素及Cox风险比例回归分析,远处转移、N分期以及内分泌治疗均为影响老年乳腺癌患者生存预后的重要因素(P<0.05)。结论 老年乳腺癌患者防止肿瘤远处转移、早期发现和内分泌治疗有利于提高生存预后。Objective To investigate and analyze the clinicopathological features,treatment and prognosis of breast cancer in elderly women. Methods 95 elderly patients with breast cancer(> 65 years old)were selected from April 2010 to July 2015.The expression of estrogen receptor(ER)and progesterone receptor(PR)in tissues were detected by immunohistochemistry.The expression of human epidermal growth factor receptor-2(HER-2)in tissues was determined by immunohistochemistry or fluorescence in situ hybridization.The clinicopathological features,treatment methods and prognosis of 95 patients were analyzed,and the influence of different factors on the prognosis of patients was analyzed. Results Among 95 cases of elderly breast cancer,the pathological type was mainly 74.74%(71/95)invasive ductal carcinoma,the tumor diameter was mainly T2(2~5cm)64.21%(61/95),lymph node metastasis was 28.42(27/95),and distant metastasis accounted for 7.37%.(7/95)The molecular type was mainly 47.37%(45/95)of Luminal A type.Univariate regression analysis and Cox risk ratio regression analysis were carried out on the factors that might affect the survival and prognosis of elderly patients with breast cancer.The results showed that distant metastasis,N stage and endocrine therapy were all important factors affecting the survival and prognosis of elderly patients with breast cancer( P <0.05). Conclusion The prevention of distant metastasis,early detection and endocrine therapy were conducive to improving survival prognosis for elderly patients with breast cancer.

关 键 词：老年 乳腺癌 病理特征 治疗方式 预后 

分 类 号：R737.9[医药卫生—肿瘤]