血必净联合有创通气治疗慢性阻塞性肺病伴急性加重患者呼吸衰竭的临床观察  

Therapeutic effect of Xuebijing Combined with Invasive Ventilation on AECOPD Respiratory Failure

作　　者：何佩娟[1] 莫蓓 李贡文[1] 章玉坤[1] HE Peijuan;MO Bei;LI Gongwen;ZHANG Yukun(Jiangxi Provincial Chest Hospital,Nanchang 330000,China)

机构地区：[1]江西省胸科医院,江西南昌330000 [2]江西省中医药大学附属医院,江西南昌330006

出　　处：《现代医院》2019年第5期720-722,共3页Modern Hospitals

基　　金：江西省中医药科技计划项目(2018B069)

摘　　要：目的观察血必净联合有创通气治疗对慢性阻塞性肺病伴急性加重(AECOPD)患者呼吸衰竭的治疗效果。方法选择2016年1月—2019年1月间医院收治的确诊为AECOPD呼吸衰竭需行有创通气的患者60例,随机分为治疗组与对照组,每组30例。对照组予以积极抗感染、支气管解痉平喘、化痰、营养支持等治疗,并行气管插管通气。治疗组在对照组基础上,静脉滴注血必净注射液。记录患者治疗前与治疗后9天的呼吸机支持参数(通气频率、压力支持、PEEP、氧浓度)、WBC计数、PCT、内毒素、血气分析值(PO2、PCO2、pH),统计所有患者治疗<9天的机械通气拔管成功率及通气时间。结果接受治疗后治疗组患者WBC、PCT计数、内毒素水平均低于观察组(P<0.05);PO2、治疗9天内拔管成功率高于对照组(P<0.05);通气时间更短。结论给予AECOPD呼吸衰竭患者有创通气治疗时,加用血必净可有效降低感染率,缩短通气时间,有利于各项生命体征的恢复,减少病死率,值得临床推广。Objective To observe the therapeutic effect of Xuebijing combined with invasive ventilation on AECOPD respiratory failure.Methods From January 2016 to January 2019,60 patients with invasive ventilation who had been diagnosed with AECOPD respiratory failure were randomly divided into treatment group and control group,30 cases in each group.The control group was treated with active anti-infection,bronchial spasm,asthma,phlegm,and nutritional support,and intubated ventilation.On the basis of the control group,the treatment group was intravenously infused with Xuebijing injection.The data were recorded on ventilator support parameters(ventilation frequency,pressure support,PEEP,oxygen concentration),WBC count,PCT,endotoxin,blood gas analysis(PO 2,PCO 2,pH)before and after treatment,and count all patients for treatment<9 days mechanical ventilation extubation success rate and ventilation time.Results After treatment,WBC,PCT count,and endotoxin levels were lower in the treatment group than in the observation group(P<0.05);PO 2,the success rate of extubation in the 9-day treatment was higher than that in the control group(P<0.05).Conclusion When invasive ventilation therapy is given to patients with AECOPD respiratory failure,the addition of Xuebijing can effectively reduce the infection rate and shorten the ventilation time,which is conducive to the recovery of vital signs and reduce the mortality rate.It is worthy of clinical promotion.

关 键 词：AECOPD 呼级衰竭 血必净 有创通气 

分 类 号：R363[医药卫生—病理学] R563.8[医药卫生—基础医学]