纳米材料在肿瘤诊疗中的应用研究进展  

Research progress on applications of nanomaterials in cancer theranostics

作　　者：尹翼鹏晨 张琴[1] 傅小龙[1] YIN Yipengchen;ZHANG Qin;FU Xiaolong(Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China)

机构地区：[1]上海交通大学附属胸科医院放疗科

出　　处：《中国癌症杂志》2019年第5期328-337,共10页China Oncology

基　　金：国家自然科学基金(81703021)

摘　　要：恶性肿瘤是目前影响人类健康的头号元凶。尽管肿瘤诊断与治疗的手段不断发展,但是由于肿瘤的异质性、隐匿性等原因,现有的肿瘤诊疗手段难以有效地克服肿瘤的复发、转移。近年来,随着纳米技术的不断发展,纳米材料因其良好的理化性质,如具有肿瘤靶向性、较好的生物相容性、易于功能化等,在肿瘤诊疗方面受到广泛关注,已有多项产品进入临床试验阶段或投入应用。对纳米材料在肿瘤诊断、化疗、放疗、光疗及免疫治疗等相关方面的应用研究进行了综述,并对其发展趋势予以了展望。Cancer is one of the leading causes of human death around the world. Despite of great advances in cancer diagnosis and treatment, also known as cancer theranostics, treatment responses, however, are often impeded by heterogeneity and stealthiness of cancer. Recently, with the fast development of nanotechnology, nanomaterials exhibit great potential in cancer theranostics for their excellent physiochemical properties including tumor targeting, good biocompatibility and easy functionalization. Moreover, a wide variety of nano-drugs have been tested in clinical trials, and some of them have been approved for human use. In this review, we aimed to provide insights into the applications of nanomaterials for innovative cancer diagnosis as well as enhanced chemotherapy,radiation therapy, phototherapy and immunotherapy of cancer. Additionally, we highlighted some examples and prospect for the further development of cancer nanotheranostics.

关 键 词：纳米诊疗体系 恶性肿瘤 靶向递药系统 

分 类 号：R730.5[医药卫生—肿瘤]