火麻仁提取液对D-GAL致衰老大鼠认知功能的影响  

Effects of Extract of Fructus Cannabis on Cognitive Function of Aging Rats Induced by D-GAL

作　　者：唐岚莹 彭均华[1] 

机构地区：[1]广西医科大学

出　　处：《大众科技》2019年第4期65-67,共3页Popular Science & Technology

基　　金：国家自然科学基金(31160209,81860205)

摘　　要：目的:探究火麻提取物(EFC)对D-半乳糖(D-gal)诱导的衰老大鼠认知的影响。方法:随机选取3月龄的雄性大鼠48只,分为6组,每组8只:正常对照组(control)、D-gal模型组、EFC(200mg/kg)预防组、EFC(400mg/kg)预防组、D-gal+EFC(200mg/kg)组、D-gal+EFC(400mg/kg)组,对各组大鼠进行Morris水迷宫的测试。结果:D-gal模型组大鼠搜索平台潜伏期增加,寻找隐藏平台的路径更曲折。而EFC(400mg/kg)预防组和治疗组大鼠潜伏期明显缩短,寻找平台的路径则比较简单。这些结果表明,EFC可以有效地预防由D-gal引起的大鼠空间记忆障碍。结论:火麻仁提取液在一定程度上可以改善D-gal致衰老大鼠的认知功能。Objectives: To investigate the effect of extract of fructus cannabis (EFC) on cognitive function of aging rats induced by D-galactose. Methods: Forty-eight three-month-old male rats were randomly selected and divided into six groups, 8 in each group: normal control group (control), D-gal model group, EFC (200 mg/kg) prevention group, EFC (400 mg/kg) prevention group, D-gal + EFC (200 mg/kg) group and D-gal + EFC (400 mg/kg) group. Morris water maze test was conducted in each group. Results: In the D-gal model group, the latency of the search platform increased, and the path to find the hidden platform was more tortuous. However, the latency of rats in EFC (400 mg/kg) prevention group and treatment group was significantly shortened, and the path to find the platform was relatively simple. These results suggest that EFC can effectively prevent D-gal-induced spatial memory impairment in rats. Conclusion: EFC can improve the cognitive function of aging rats induced by D-gal to a certain extent.

关 键 词：火麻仁提取液 认知 记忆 

分 类 号：R363[医药卫生—病理学]