简阳市育龄夫妇地中海贫血筛查结果分析  

Thalassemia screening of married couples,Jianyang

作　　者：樊建平 卓玛拉措 李斯怡 栾荣生[2] 高哲飞 孙晓蒙[2] 陈红英 徐耀明 FAN Jian-ping;ZHUO MA La-cuo;LI Si-yi;LUAN Rong-sheng;GAO Zhe-fei;SUN Xiao-meng;CHEN Hong-ying;XU Yao-ming(Maternal and Child Health and Family Planning Service Center of Jianyang City,Chengdu,Sichuan 641400,China)

机构地区：[1]简阳市妇幼保健计划生育服务中心,四川成都641400 [2]四川大学华西公共卫生学院/四川大学华西第四医院,四川成都610041

出　　处：《现代预防医学》2019年第11期2066-2069,共4页Modern Preventive Medicine

摘　　要：目的分析四川省简阳市育龄人群地贫筛查结果,以便为简阳市地贫筛查规划提供参考依据。方法对2016-2017年在简阳市妇保院接受地贫筛查的育龄夫妇采用红细胞指标检测(MCV和MCH)和血红蛋白电泳(HbA2、HbF和异常血红蛋白)分析进行实验室筛查,初筛阳性夫妇进行基因检测确诊。运用SPSS 20. 0进行统计分析,统计描述采用率、构成比等指标,统计分析采用t检验、χ^2检验等。结果 2016-2017年在简阳市妇保院接受地贫筛查的对象共6216名(3 108对育龄夫妇),平均年龄为(25. 65±4. 46)岁。男女间MCV值(t=-19. 464,P <0. 05)、MCH值(t=6. 740,P <0. 05)、HbF值(t=-11. 986,P <0. 05)的差异具有统计学意义;简阳市和非简阳市户籍人群MCV值(t=-2. 036,P <0. 05)的差异具有统计学意义。夫妇初筛阳性的比例为2. 06%。地贫基因携带者占筛查人群的0. 56%(35/6 216),同型地贫基因携带夫妇占筛查夫妇的0. 29%(9/3 108)。结论简阳市育龄人群地贫基因携带率较高,开展育龄夫妇地贫筛查,对促进优生优育和提高人口素质具有重要意义。Objective To analyze the thalassaemia screening results of married couples,and to provide a reference for the screening program of thalassaemia in Jianyang city.Methods The red blood cell index test(MCV and MCH)and hemoglobin electrophoresis(HbA2,HbF and abnormal hemoglobin)were used to screen married couples who were screened for thalassaemia in Jianyang Maternal and Child Health and Family Planning Service Center from 2016 to 2017.Primary screening positive couples accepted thalassemia gene detection.The SPSS 20.0 software was used for statistical analysis.Rate and constituent ratio were used in the statistical description,while the t-test and chi-square test were used for statistical analysis.Results A total of 6 216 objectives(3 108 married couples)were analyzed,with an average age of 25.65±4.46.The MCV value(t=-19.464,P<0.05),MCH value(t=6.740,P<0.05),and HbF value(t=-11.986,P<0.05)were statistically significant between male and female.Besides,the index values were compared between with and without Jianyang householder register,which showed that the MCV value(t=-2.036,P<0.05)was statistically significant.The primary screening positive rate among the couples was 2.06%.Thalassemia gene carriers accounted for 0.56%(35/6 216)of the screening population.And the rate of carrying the same type of thalassemia gene accounted for 0.29%(9/3 108)among the screening couples.Conclusion The carrying rate of thalassemia gene is high among married couples in Jianyang city.Conducting the screening for thalassaemia is of great significance for prepotency promotion and improvement of population quality.

关 键 词：地中海贫血 育龄人群 筛查 简阳市 

分 类 号：R181.37[医药卫生—流行病学]