血脑屏障通透性定量评估及其在急性缺血性卒中患者中的应用  

Quantitative assessment of blood-brain barrier permeability and its application in patients with acute ischemic stroke

作　　者：霍礼功 王钰 陈蓓蕾 于海龙 李军[1] Huo Ligong;Wang Yu;Chen Beilei;Yu Hailong;Li Jun(Department of Neurology,Clinical Medicine College of Yangzhou University,Jiangsu Subei People's Hospital,Yangzhou 225009,China)

机构地区：[1]扬州大学临床医学院,江苏省苏北人民医院神经内科,225009

出　　处：《国际脑血管病杂志》2019年第4期287-293,共7页International Journal of Cerebrovascular Diseases

摘　　要：缺血性卒中的发生、发展和再灌注治疗过程中可能对血脑屏障结构和功能造成破坏,导致血脑屏障通透性增加,进而出现脑水肿或出血性转化,最终造成转归不良。目前已可对血脑屏障通透性进行定量评估。文章就血脑屏障通透性评估方法及其在缺血性卒中患者中的应用进行了综述。The occurrence, development and reperfusion treatment of ischemic stroke may damage the structure and function of the blood-brain barrier, leading to increased permeability of the blood-brain barrier, and then having cerebral edema or hemorrhagic transformation, and finally resulting in poor outcome. Quantitative assessment of blood-brain barrier permeability is now available. This article reviews the assessment methods of blood-brain barrier permeability and their application in patients with ischemic stroke.

关 键 词：卒中 脑缺血 血脑屏障 通透性 磁共振成像 体层摄影术 X线计算机 

分 类 号：R743.3[医药卫生—神经病学与精神病学]