自噬及其相关蛋白在牙周病发生发展中作用的研究进展  

Advances in research of autophagy and its related proteins in periodontal disease

作　　者：宋璐 谭静怡[1] 陈莉丽[1] Song Lu;Tan Jingyi;Chen Lili(Department of Periodontology, The Second Affiliated Hospital of Zhejiang University of Medicine, Hangzhou 310009, China)

机构地区：[1]浙江大学医学院附属第二医院牙周病专科,杭州310009

出　　处：《中华口腔医学杂志》2019年第5期339-343,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81771072、81800972)。

摘　　要：牙周病是以牙龈炎症和牙槽骨进行性破坏为特征的慢性感染性疾病,菌斑微生物和宿主防御之间的相互作用影响疾病的过程和进展。新近研究发现,自噬是一种最原始的对抗病原微生物入侵的宿主防御反应,具有清除病原体,调控炎症反应等功能,且在炎症因子作用下促进破骨细胞活化,影响骨吸收功能,在牙周病的发生发展中发挥重要作用。本综述总结国内外文献,重点介绍自噬机制,自噬及其相关蛋白与牙周病的关系,阐述自噬与牙周致病菌、炎症反应及破骨细胞骨吸收的作用机制,以期丰富牙周病的发病机制,为牙周病的治疗提供新的视角。Periodontal disease is a chronic infectious disease characterized by gingival inflammation and progressive destruction of alveolar bone, and the interaction between plaque microbes and host defense affects the process of the disease. Recent studies have found that autophagy is one of the most primitive host defense responses against pathogenic microbial invasion. Autophagy plays an important role in the development of periodontal disease through such functions as clearing pathogens, regulating inflammatory responses and promoting osteoclast activation to affect bone resorption with inflammatory factors. This review article mainly introduces the research advances on autophagy mechanism and the relationship between autophagy and periodontal disease from the domestic and foreign literatures and expounds the mechanism of autophagy and periodontal pathogens, inflammatory reaction and bone resorption of osteoclasts, so as to enrich the pathogenesis of periodontal disease and provide a new perspective for the treatment of periodontal disease.

关 键 词：牙周疾病 自噬 炎症 骨吸收 

分 类 号：R781.4[医药卫生—口腔医学]