柴胡加龙骨牡蛎汤联合氟哌噻吨美利曲辛片治疗卒中后抑郁  

The clinical trials of Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets for the post-stroke depression

作　　者：高晔 张颖洁[2] Gao Ye;Zhang Yingjie(Department of Geriatrics,Harrison International Peace Hospital of Hengshui,Hengshui 053000,China;Department of Nursing,Harrison International Peace Hospital of Hengshui,Hengshui 053000,China)

机构地区：[1]河北省衡水市哈励逊国际和平医院老年病一科,053000 [2]河北省衡水市哈励逊国际和平医院护理部,053000

出　　处：《国际中医中药杂志》2019年第5期447-450,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨柴胡加龙骨牡蛎汤联合氟哌噻吨美利曲辛片对卒中后抑郁(post-stroke depression, PSD)患者血清脂联素(adiponectin, APN)水平及抑郁状态的影响。方法将符合入选标准的150例PSD患者采用随机数字表法分为2组,每组75例。在常规脑卒中治疗基础上,对照组口服氟哌噻吨美利曲辛片,观察组在对照组基础上加服柴胡加龙骨牡蛎汤。2组均治疗1个月。采用ELISA法检测APN浓度,采用汉密尔顿抑郁量表(Hamilton Depression Rating Scale, HAMD)评估抑郁程度,采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)评估神经功能缺损程度,评价临床疗效。结果观察组总有效率为81.3%(61/75)、对照组为58.7%(44/75),2组比较差异有统计学意义(χ2=8.127,P=0.004)。治疗后,观察组血清脂联素[(7.8±3.7)mg/L比(6.1±3.3)mg/L,t=2.970]水平高于对照组(P<0.05);HADM评分[(16.4±3.6)分比(19.6±4.9)分,t=4.558]、NIHSS评分[(5.0±1.6)分比(7.7±2.0)分,t=9.129]均低于对照组(P<0.01)。结论柴胡加龙骨牡蛎汤联合氟哌噻吨美利曲辛片可降低PSD患者的血清脂联素水平,改善患者抑郁状态及神经功能缺损程度。Objective To observe the effect of Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets for the post-stroke depression (PSD).Methods The random number table method was used to divide the 150 patients with PSD into the observation group and control group,75 cases in each group.On the basis of conventional treatment of stroke,the control group took oral flupentixol and melitracen tablets,and the treatment group add Chaihu-Longgu-Muli decoction on the basic treatment of control gorup.The treatment of two groups last 1 month.The serum APN concentration was detected before and after treatment.Besides,the HAMD,NIHSS scores,and the clinical curative effect were observed and compared.Results The total effective rate of the observation group was 81.3%,and control group was 58.7%,which the difference between the two groups showed the statistical significance (P<0.05).After treatment,the serum APN (7.8 ± 3.7 mg/L vs.6.1 ± 3.3 mg/L,t=2.970) level in the observation group was significantly higher than that in the control group (P<0.05).The HADM (16.4 ± 3.6 vs.19.6 ± 4.9,t=4.558),NIHSS (5.0 ± 1.6 vs.7.7 ± 2.0,t=9.129) scores in the observation group were significantly lower than those in the control group (P<0.01).Conclusions The Chaihu-Longgu-Muli decoction combined flupentixol and melitracen tablets can reduce the serum APN level of PSD patients,improve patients with depression,alleviate patients' neurologic deficits.

关 键 词：卒中 抑郁症 柴胡加龙骨牡蛎汤 脂联素 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]