MRT1WI增强全瘤纹理分析在鉴别囊性胶质瘤与脑脓肿的价值  

The value of wholeGtumor texture analysis of contrastGenhanced T1 WI in differentiating cystic glioma from brain abscess

作　　者：屈耀铭 王显龙[1] 于昊[1] 黄文彦 朱建彬[1] 温志波[1] QU Yaoming;WANG XianLong;YU Hao;HUANG Wenyan;ZHU Jianbin;WEN Zhibo(Department of Radiology,Zhujiang Hospital of Southern Medical University,Guangzhou 510282, China;Department of Pathology ,Zhujiang Hospital of Southern Medical University,Guangzhou 510282, China)

机构地区：[1]南方医科大学珠江医院放射科,广东广州510282 [2]南方医科大学珠江医院病理科,广东广州510282

出　　处：《实用放射学杂志》2019年第6期857-860,868,共5页Journal of Practical Radiology

基　　金：广东省科技计划项目(2014A020212726)。

摘　　要：目的探讨T1WI增强全瘤纹理分析在鉴别囊性胶质瘤(CG)与脑脓肿(BA)的价值。方法回顾性分析经病理证实的25 例环形强化CG与 24 例BA患者的 MRI资料.患者术前均行颅脑MRI平扫及增强扫描。运用FireVoxel软件勾画全瘤ROI。得到3D ROI的信号强度直方图及相关纹理参数,包括平均值、中位数、标准差、不均匀性、偏度、峰度及熵值。先将数据进行正态性检验,采用独立样本t检验(正态分布)或MannGWhitney 秩和检验(偏态分布)比较CG和BA纹理参数的差异.采用 ROC曲线评价各参数鉴别CG和BA的效能。结果平均值、中位数、标准差、不均匀性和偏度在CG和BA间的差异有统计学意义(P<0.05),峰度与熵值的组间差异无统计学意义(P>0.05)。T1WI增强全瘤纹理分析参数中,不均匀性鉴别CG和BA的AUC最大(0.988),阈值取0.314 时,敏感度和特异度分别为 92.60%和 97.10%。结论 T1WI增强序列全瘤纹理分析的部分定量参数(平均值、中位数、标准差、不均匀性和偏度)有助于影像鉴别CG和BA,为术前诊断提供可靠的客观证据。Objective To evaluate the feasibility of wholeGtumor texture analysis of contrastGenhanced T1 WI (T1 Ce)in differentiating cystic glioma (CG)from brain abscess (BA).Methods MRI data of 25 cases of ringGenhanced CG and 24 cases of BA proven pathologically were retrospectively studied.All the patients underwent preGsurgery MRI plain and contrastGenhanced scans.FireVoxel software was used to outline the ROI of the wholeGtumor.The signal intensity histogram and related texture parameters of the 3D ROI were obtained,including mean, median,standard deviation,inhomogeneity,skewness,kurtosis and entropy.The data were first tested for normality and the differences in wholeG tumor texture analysis parameters of T1 Ce between CGs and BAs were compared using the independentGsample t test(normal distribution)and MannGWhitney rank sum test (skewed distribution).ROC curve was used to evaluate the efficacy of the parameter in differentiating CG from BA.Results There were statistical significances in the parameters of mean,median,standard deviation,inhomogeneity and skewness between CGs and BAs(P<0.05),and there were no any statistical significances in kurtosis and entropy between CGs and BAs(P>0.05).In all the texture parameters,the AUC of inhomogeneity was the largest(0.988),and when the threshold was 0.314, the sensitivity and the specificity were 92.60% and 9 7.1 0%,respectively.Conclusion Some of the quantitative parameters of the wholeGtumor texture analysis of T1 Ce(mean,median,standard deviation,inhomogeneity and skewness)could provide reliable and objective evidences for imaging differential diagnosis of CG and BA preGsurgery.

关 键 词：脑肿瘤 囊性胶质瘤 脑脓肿 纹理分析 磁共振成像 

分 类 号：R739.41[医药卫生—肿瘤] R742.7[医药卫生—临床医学]