不同b值扩散加权成像信号强度联合表观扩散系数值在前列腺癌诊断中临床应用分析  

The clinical application of DWI signal intensity at different b values and ADC value in diagnosis of prostatic cancer

作　　者：谢玮慧 夏国金[2] 龚洪翰[2] 姜建[2] 曾献军[2] XIE Weihui;XIA Guojin;GONG Honghan;JIANG Jian;ZENG Xianjun(Medical College of Nanchang University,Nanchang 330006,China;Department of Radiology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学医学院,江西南昌330006 [2]南昌大学第一附属医院影像科,江西南昌330006

出　　处：《实用放射学杂志》2019年第6期981-984,1018,共5页Journal of Practical Radiology

基　　金：江西省卫生计划生育健康委员会科技计划项目(20175126)。

摘　　要：目的探讨1.5TMRI的DWI信号强度和ADC对鉴别前列腺增生(BPH)和前列腺癌(PCa)的诊断价值。方法回顾性分析经病理证实的PCa和BPH患者43例,其中PCa21例,BPH22例,均已行1.5TMRIDWI,在DWI图上,分别测量b=800s/mm^2、b=1600s/mm^2时ROI的信号强度;在b=1600s/mm^2时的ADC图上测量ROI的ADC值.用两独立样本t检验分析PCa组与BPH组ADC值、信号强度的差异,用ROC曲线分析不同b值下DWI信号强度及ADC值对PCa的诊断效能。结果PCa与BPH在b=800s/mm^2、b=1600s/mm^2时的信号强度以及b=1600s/mm^2时的ADC值之间比较差异均有统计学意义(P<0.05);b=1600s/mm^2时的ADC值对PCa的诊断效能最高,b=1600s/mm^2时的DWI信号强度次之,b=800s/mm^2时的DWI信号强度较前两者略差。结论DWI信号强度与ADC值均有助于PCa的诊断,并且b=1600s/mm^2时的ADC值对PCa的诊断效能最高。Objective To explore the value of DWI and ADC in differential diagnosis of benign prostatic hyperplasia (BPH)and prostatic cancer(PCa).Methods The data of 43 patients with BPH or PCa proven by histopathology were retrospectively reviewed. There were 21 patients with PCa and 22 patients with BPH.All of the patients were examined by DWI at 1.5T MRI.On the DWI,signal intensities in ROI were measured at the b value of 800s/mm^2 and 1 600s/mm^2 ,respectively.On the ADC map,ADC values in ROI were measured.The differences of the ADC values and the signal intensities of DWI were compared between the benign BPH and the PCa by using independent sample tGtest.Diagnostic efficiency of the signal intensity and the ADC value for PCa were analyzed by using ROC curve.Results There were statistically significant differences of the ADC values and the signal intensities of DWI at the b value of 800s/mm^2 and 1 600 s/mm^2 between the BPH and the PCa (P<0.05).The ADC at the b value of 1600s/mm^2 had the highest diagnostic efficiency,the DWI at the b value of 1 600 s/mm^2 took a second place,and the DWI at the b value of 800s/mm^2 was worst.Conclusion DWI and ADC are helpful for the diagnosis of PCa,and ADC at b value of 600s/mm^2 has the highest diagnostic efficiency.

关 键 词：前列腺癌 前列腺增生 扩散加权成像 表观扩散系数 磁共振成像 

分 类 号：R737.25[医药卫生—肿瘤] R697.3[医药卫生—临床医学]