miR-132/212在AD相关认知功能障碍中的研究进展  

Research Progress of miR-132/212 in AD Related Cognitive Disorder

作　　者：陈盼盼 齐玉英 郑海非 杨红彦 王雪贞[1,2] CHEN Panpan;QI Yuying;ZHENG Haifei;YANG Hongyan;WANG Xuezhen(Department of Neurology,Binzhou Medical University Hospital,Binzhou 256603,China;Institute of Metabolism and Neuropsychiatric Disorders,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院神经内科,山东滨州256603 [2]滨州医学院附属医院代谢与神经精神疾病研究所,山东滨州256603

出　　处：《医学综述》2019年第11期2092-2096,共5页Medical Recapitulate

基　　金：国家自然科学基金(81400903);山东省医药卫生科技发展计划(2017WS157)

摘　　要：阿尔茨海默病(AD)是一种大脑神经元的神经退行性病变,主要由神经元细胞外β淀粉样蛋白沉积和细胞内Tau蛋白过度磷酸化形成的老年斑和缠结的神经纤维导致。现阶段对AD的确切发病机制还不十分清楚,尚无有效的治疗能预防和阻止AD相关认知功能的进展。微RNA(miRNAs)参与转录后基因表达调控,通过调节淀粉样蛋白前体或β分泌酶1等基因参与AD发病过程,近年来对miRNAs的研究成为热点。在AD大脑和脑脊液中miRNAs的表达改变,其中miR-132/212备受关注。Alzheimer′s disease(AD) is a neurodegenerative disease of the brain neuron, caused mainly by extracellular accumulations of amyloid-β protein in the form of plaques and intracellular tangles, consisting of hyperphosphorylated Tau proteins. The exact pathogenic mechanisms resulting in AD remain unknown,and no efficient clinical treatment can prevent developing of AD related cognitive disorder.MicroRNAs(miRNAs) are involved in posttranscriptional gene expression regulation and participate in the pathogenesis of AD by regulating genes such as amyloid precursor protein or β-secreatase 1.In recent years, miRNAs have become a hot research topic.Many studies have identified miRNAs expression changes in AD brain and cerebrospinal fluid,and miR-132/212 has attracted a lot of attention.

关 键 词：阿尔茨海默病 miR-132/212 认知功能 Β淀粉样蛋白 TAU蛋白 

分 类 号：R741.05[医药卫生—神经病学与精神病学]