干眼症发病机制与发病因素的研究进展  

Research Development of Pathogenesis and Influence Factors in Xerophthalmia

作　　者：唐颖 田甜 葛红岩[1] TANG Ying;TIAN Tian;GE Hongyan(Department of Ophthalmology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科

出　　处：《医学综述》2019年第11期2196-2201,共6页Medical Recapitulate

基　　金：黑龙江省自然科学基金面上项目(H2017028)

摘　　要：干眼症的发病率逐年升高,已成为最常见的眼部疾病之一。目前,干眼症的治疗仍以人工泪液缓解症状为主。近年来,对干眼症发病机制的研究已不再局限于泪液分泌不足和泪液蒸发增加,而是涉及泪膜稳定性、泪液渗透压、神经感觉异常及眼表炎症等多方面,其中眼表产生的细胞因子是研究热点。环境、年龄、性别、全身性因素等也是干眼症发病的因素,医源性因素逐渐引起临床医师的重视。分析干眼症的发病机制及发病因素,有利于对干眼症进行分类、检查、诊断及治疗,提高患者的视觉质量。Xerophthalmia has become one of the most common eye diseases with increasing incidence year by year.At present,the treatments still rely on artificial tear.In recent years,the research on the pathogenesis of xerophthalmia is no longer limited to simple insufficient lacrimal secretion or increased evaporation,but involves many aspects such as tear film stability,tear osmotic pressure,nerve sensory abnormalities and ocular surface inflammation.And the activity of ocular surface cytokines has become a hot topic.The study on the factors of xerophthalmia involves environment,age,sex,systemic factors and so on,among which iatrogenic factors have been paid more and more attention by the clinicians. The analysis of the pathogenesis and factors of xerophthalmia is crucial to the classification,examination,diagnosis and treatment,so as to improve the visual quality of the patients.

关 键 词：干眼症 细胞因子 病理生理机制 致病因素 

分 类 号：R777.34[医药卫生—眼科]