扶正祛邪汤联合化疗分期干预乳腺癌术后(正虚毒盛)随机平行对照研究  被引量:7

Fuzheng Quxie Decoction(扶正祛邪汤) combined with Chemotherapy Stage Intervention for Postoperative Breast Cancer(Zhengxu Dusheng/正虚毒盛) Randomized Parallel Controlled Study

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作  者:董淑珺 DONG Shujun(Surgery of Traditional Chinese Medicine in Dengfeng Hospital of Traditional Chinese Medicine,Dengfeng452470,Henan,China)

机构地区:[1]登封市中医院中医外科,河南登封452470

出  处:《实用中医内科杂志》2019年第3期30-33,共4页Journal of Practical Traditional Chinese Internal Medicine

摘  要:[目的]观察扶正祛邪汤联合化疗方法治疗乳腺癌术后(正虚毒盛)疗效。[方法]使用随机平行对照方法,将45例住院患者按病志号抽签随机分为两组。对照组22例CMF方案:环磷酰胺,500mg/m^2,dl、d8,静推;甲氨蝶呤,50mg/m^2,dl、d8,静推;氟尿嘧啶,500mg/m^2,dl、d8,静推。治疗组23例扶正祛邪汤(人参、白术、白茯苓、当归、川芎、白芍药、鹿角胶、肉苁蓉、地黄~熟、甘草~炙各30g,白花蛇舌草、露蜂房、半枝莲各20g,柴胡、郁金、香附、陈皮、姜~生、半夏、连翘、佩兰、紫花地丁各15g),水煎400mL,1剂/d,早晚温服;CMF方案同对照组。连续治疗28d为1疗程。观测临床表现、NK细胞、CD4^+、CD8^+、卡氏评分、不良反应。连续治疗2疗程(56d),判定疗效。[结果]卡氏评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。NK、CD4^+、CD8^+两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。情绪低落、恶心呕吐、腹泻等不良反应发生率治疗组低于对照组(P<0.05),脱发两组无显著差异(P>0.05)。[结论]扶正祛邪汤联合化疗方法治疗乳腺癌术后(正虚毒盛),疗效满意,值得推广。[Objective] To observe the curative effect of Fuzheng Quxie decoction combined with chemotherapy in the treatment of breast cancer after operation(Zhengxu Dusheng).[Method] 45 hospitalized patients were randomly divided into two groups by drawing lots according to the disease sign by random parallel control method. In the control group, 22 cases of CMF were treated with cyclophosphamide, 500 mg/m^2, dl, d8, intravenous push, methotrexate, 50 mg/m^2, dl, d8, intravenous push, fluorouracil, 500 mg/m^2,dl, d8, intravenous push. The treatment group consisted of 23 cases of Fuzheng Quxie decoction(Renshen,Baizhu, Baifuling, Danggui, Chuanxiong, Baishao, Lujiaojiao, Roucongrong, Shudihuang, Zhigancao each 30 g,Baihuasheshecao, Lufengfang, Banzhilian each 20 g, Chaihu, Yujin, Chenpi, Shengjiang, Banxia, Lianqiao,Peilan, Zihuadiding each 15 g), decocted 400 mL in water, 1 dose/day, warm Continuous treatment for 28 days is a course of treatment. Clinical manifestations, NK cells, CD4^+, CD8^+, Karl’s score and adverse reactions were observed. Continuous treatment for 2 courses(56 days) to determine the efficacy.[Result] The Karl’s score was improved in both groups(P<0.01), and the improvement in the treatment group was better than that in the control group(P<0.01). NK, CD4^+, CD8^+ were improved in both groups(P<0.05, P<0.01), and the improvement in treatment group was better than that in control group(P<0.05, P<0.01). The incidence of adverse reactions such as depression, nausea, vomiting and diarrhea in the treatment group was lower than that in the control group(P<0.05), and there was no significant difference in alopecia between the two groups(P>0.05).[Conclusion] Fuzheng Quxie decoction combined with chemotherapy for breast cancer after operation(Zhengxu Dusheng) has satisfactory curative effect and is worthy of promotion.

关 键 词:乳腺癌 乳岩 扶正祛邪汤 化学疗法 NK细胞 CD4^+ CD8^+ 卡氏评分 中药复方 随机平行对照研究 

分 类 号:R737.9[医药卫生—肿瘤]

 

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