牙源性干细胞及牙髓再生的研究进展  

Research progress in stem cells of dental origin and dental pulp regeneration

作　　者：王恒心 王思拓 伍美玲 李蓓 WANG Heng-xin;WANG Si-tuo;WU Mei-ling;LI Bei(State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China)

机构地区：[1]军事口腔医学国家重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病国际联合研究中心第四军医大学口腔医院组织病理学教研室,陕西西安710032 [2]军事口腔医学国家重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心第四军医大学口腔医院儿童口腔科,陕西西安710032

出　　处：《中国实用口腔科杂志》2019年第5期312-316,共5页Chinese Journal of Practical Stomatology

基　　金：国家自然科学基金项目(81870768);陕西省人才推进计划-青年科技新星项目(2018KJXX-015)

摘　　要：牙髓组织中含有细胞、血管、神经和纤维等,是一个复杂的3D结构系统。随着干细胞生物学和组织工程学的相互结合和促进,牙髓再生逐渐成为可能。牙体组织中分离出的多种干细胞,如牙髓干细胞、脱落乳牙牙髓干细胞、根尖牙乳头干细胞、牙囊干细胞等,都具有再生牙髓的潜能。文章就牙源性干细胞及以牙源性干细胞为基础的牙髓再生的研究进展做一综述。The dental pulp is a complicated 3D structure consisting of cells,blood,nerve and fiber. Recently,advances in stem cell biology and tissue engineering accelerate the development of dental pulp regeneration. Numerous types of stem cells have been isolated from dental tissue,such as dental pulp stem cells(DPSCs),stem cells from human exfoliated deciduous teeth(SHED),stem cells from the apical papilla(SCAP),and dental follicle stem cells(DFSCs). All these cells can regenerate dental pulp. This review outlines the cell types of stem cells of dental origin and the research progress of dental pulp regeneration based on these cells.

关 键 词：牙髓再生 干细胞 细胞工程 

分 类 号：R78[医药卫生—口腔医学]