聚β-羟基丁酸酯提取方法研究进展  

Research progress on extraction methods of poly-β-hybroxybutyricacid

作　　者：许锡凯 辛嘉英[1,2] 盆璐 李家柔 林雪 XU Xikai;XIN Jiaying;PEN Lu;LI Jiarou;LIN Xue(Key Laboratory for Food Science and Engineering,Harbin University of Commerce,Harbin 150076,China;State Key Laboratory for Oxo Synthesis & Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China)

机构地区：[1]哈尔滨商业大学食品科学与工程重点实验室,黑龙江哈尔滨150076 [2]中国科学院兰州化学物理研究所羰基合成和选择氧化国家重点实验室,甘肃兰州730000

出　　处：《发酵科技通讯》2019年第2期79-84,共6页Bulletin of Fermentation Science and Technology

基　　金：国家自然科学基金资助项目(21573055);山西省优秀人才科技创新项目(201705D211029)

摘　　要：聚β-羟基丁酸酯(PHB)具有生物可降解性、生物相容性等多种特性,其广泛应用于医疗组织工程和工农业等方面。由于PHB的用途广泛,其提取显得尤为重要。PHB的提取方法除了溶剂提取法、酶法、次氯酸钠氯仿提取法、高压匀浆法和珠磨法等常用方法外,还有螯合剂法、噬菌体裂解法、超声破碎法、基因工程法、直接成型法、化学法合成和从活性污泥中提取PHB等其他方法。对这些提取方法进行介绍,并展开比较分析。在未来的研究中,PHB的提取会向着更加无污染、低成本的方向发展。Poly-β-hybroxybutyricacid(PHB)has many properties such as biodegradability and biocompatibility,and is widely used in medical tissue engineering,industry and agriculture.Due to the wide uses of PHB,the extraction of PHB is particularly important.In addition to the solvent extraction method,enzymatic method,sodium hypochlorite chloroform extraction method,high-pressure homogenization method and bead milling method,the extraction method of PHB also includes a chelating agent method,a phage lysis method,an ultrasonic pulverization method,and genetic engineering method.These PHB extraction methods were introduced and compared.Finally,environmentally friendly,low-cost PHB extraction methods were discussedfor the future development.

关 键 词：PHB 可降解性 相容性 提取方法 

分 类 号：Q93[生物学—微生物学]