瞬时受体电位通道和消化系肿瘤的关系研究进展  

Advances in research of the relationship between transient receptor potential channels and digestive cancers

作　　者：侯常青 庹必光[2] HOU Changqing;TUO Biguang(Zunyi Medical College Medical and Biological Research Center,Zunyi 563000,China;Department of Gastroenterology,Affiliated Hospital of Zunyi Medical College,Zunyi 563000)

机构地区：[1]遵义医学院医学与生物学研究中心,贵州遵义563000 [2]遵义医学院附属医院消化科,贵州遵义563000

出　　处：《中国比较医学杂志》2019年第6期129-134,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金资助项目(81572438)

摘　　要：瞬时受体电位通道(transient receptor potential channels,TRPC)是位于细胞膜上的一类重要的阳离子通道,在呼吸道、消化道、肝脏和心脏等组织器官都有表达。近来的研究表明TRPC参与了肿瘤的发生发展。本文综述了TRPC在消化系统肿瘤发生发展及治疗中的作用,希望进一步了解消化系统肿瘤发生发展的机制,为消化系统肿瘤的治疗提供另一个方向进行探讨.Transient receptor potential(TRP)channels,which are important selective cation channels located in the cell membrane,are widely expressed in the human respiratory tract,digestive tract,liver,and heart.Many studies have demonstrated the involvement of TRP channels in the development and progression of malignant tumors.Herein,we review the roles of TRP channels in the development,progression,and treatment of digestive tumors.We hope to provide further understanding of the mechanisms of pathogenesis and progression of digestive cancers,as well as an alternative direction for their treatment.

关 键 词：TRP通道 消化系肿瘤 诊断 治疗 

分 类 号：R-33[医药卫生]