丁苯酞对血管性痴呆的疗效Meta分析  

A meta-analysis of butylphthalide therapy for vascular dementia

作　　者：王凡 王向阳 刘丽[1] 常利[1] 宋志秀[1] 李合华[1] 李彤[1] WANG Fan;WANG Xiangyang;LIU Li;CHANG Li;SONG Zhixiu;LI Hehua;LI Tong(Department of Neurology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China)

机构地区：[1]新乡医学院第一附属医院神经内科

出　　处：《中国实用神经疾病杂志》2019年第10期1059-1063,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的评价丁苯酞治疗血管性痴呆的临床疗效。方法系统检索万方数据库、中国期刊全文数据库、维普中文科技期刊数据库、PubMed数据库、Embase数据库和Ovid数据库进行检索,逐一对文献进行质量评价,提取有效数据,采用RevMan5.3软件进行Meta分析。结果最终纳入8个随机对照试验,丁苯酞在改善血管性痴呆患者的简易精神状态检查量表(MMSE)评分及日常生活能力量表(ADL)评分方面优于对照组,差异有统计学意义。结论丁苯酞能改善血管性痴呆患者MMSE评分及ADL评分,且安全性较好。Objective To evaluate the clinical curative properties of butylphthalide soft capsules on treating vascular dementia. Methods A systematic research was conducted by searching six databases,Wanfang,CNKI,VIP,PubMed,Embase and Ovid.Evaluating the quality of the documents one by one,extracting the valid data,and adopting Rev Man 5.3 software to Meta analyze. Results Bringing eight randomized controlled experiments into the research,we found that butylphthalide soft capsules did better in improving the grades of MMSE(mini mental state examination) and ADL(Activities of daily living),and the difference is very meaningful to statistics. Conclusion Butylphthalide soft capsules can improve the grade of MMSE and ADL,and it is very safe.

关 键 词：丁苯酞 血管性痴呆 META分析 MMSE评分 ADL评分 

分 类 号：R749.13[医药卫生—神经病学与精神病学]