胆红素在缺血性脑梗死中的意义及研究进展  

Significance and research progress of bilirubin in ischemic cerebral infarction

作　　者：张迎春 杨谦[2] ZHANG Yingchun;YANG Qian(Xi’an Medical College,Xi’an 710068,China;Department of Neurology,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)

机构地区：[1]西安医学院,陕西西安710068 [2]陕西省人民医院神经内科,陕西西安710068

出　　处：《中国实用神经疾病杂志》2019年第10期1152-1156,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：脑卒中是全世界第二大死因,在我国脑血管病已升至首位疾病死亡原因,现患病人数高居世界首位,因其高发病率、高病死率和高致残率,给社会和家庭均带来沉重的经济负担。胆红素一直被认为是血红素氧化酶和胆绿素还原酶协同作用产生的血红素代谢废物。最近研究表明,胆红素是体内重要的内源性抗氧化剂,具有抗炎、抗氧化、抗动脉粥样硬化和神经细胞保护作用等特性,在脑血管病中发挥有益作用。本文就胆红素与脑血管疾病关系的研究进展作一综述。Stroke is the second leading cause of death in the world.Cerebrovascular disease has risen to the first cause of death in China.The number of patients is the highest in the world due to its high incidence,high mortality and high disability rate.Both society and the family bring a heavy economic burden.Bilirubin has long been recognized as a heme metabolism waste produced by the synergy of heme oxygenase and biliverdin reductase.Recent studies have shown that bilirubin is an important endogenous antioxidant in the body,with anti inflammatory,anti oxidation,anti atherosclerosis and neuroprotective effects,and plays a beneficial role in cerebrovascular disease.This article reviews the research progress of the relationship between bilirubin and cerebrovascular diseases.

关 键 词：脑梗死 胆红素 动脉粥样硬化斑块 卒中后抑郁 

分 类 号：R743.33[医药卫生—神经病学与精神病学]